hot sell small molecular api erlotinib(cas# 183321-74-6) chemical information:product name erlotinibmolecular formula c22h23n3o4molecular weight 393.44storage store at -20ctargets egfric50 2 nmoriginal wuhan, chinabrand name newbiopurity 99%appearance white powderpackage 100gbag; 1kgbag or as requiredshipping fast and secure shipping by dhl, ems, ups, fedex.shipping leading time within 12 hours after receiving the paymentpayment terms western union, , tt, bitconmoq 100gsupply ability mass stock description:erlotinib is an egfr inhibitor with ic50 of 2nm, >1000-fold more sensitive for egfr than human c-src or v-abl. application:at doses of 100 mgkg, erlotinib hcl completely prevents egf-induced autophosphorylation of egfr in human hn5 tumors growing as xenografts in athymic mice and of the hepatic egfr of the treated mice. erlotinib hcl (100 mgkg) inhibits h460a and a549 tumor models with 71 and 93% inhibition rate.erlotinib inhibits purified egfr tyrosine kinase and egfr autophosphorylation intact cells with 50% inhibition concentration ic50 values of 2nmoll and 20 nmoll respectively. erlotinib competes for the atp-binding sits on the intracellular domain of egfr resulting in the inhibition of downstream signaling pathway involved in angiogenesis, cell propagation and cell survival. erlotinib concentration-dependently inhibits egfr-mediated propagation signals transduction, displays prominent anti-tumor activity against neoplasms harboring egfr expression and exhibits atolerable toxicologic profile.