Fact About Grapes There are several hundred widely different cultivars of grapes grown in the United States. The cultivars are grouped into four types: (1) European (Vitis vinifera), (2) American (Vitis labrusca and its derivatives), (3) Muscadine (Vitis rotundifolia) and (4) French hybrids, crosses of V. vinifera cultivars with disease-resistant wild American species.