BIO-TENSE BIO REACTOR

The BioTense Perfusion Bioreactor is a next generation instrument designed to help tissue engineers and cell biologists perform high resolution investigation in Mechanobiology. BioTense sits atop the XYZ stage of an inverted microscope.

• Enables cells to proliferate and differentiate over
• long periods of time
• Maintains desired concentrations of nutrients through a perfusion process
• Exposes tissues to uniaxial force and strain fields
• Provides a window to directly observe cellular activity at high magnification
• Accurately controls reactor temperature
• Minimizes dead space volume with adjustable height chamber
• Load capacities 7Newtons
• Testing speed range: up to 1.2 mm/sec
• Position control resolution down to 0.005mm
• Piston strokes up to 25mm
• 32 bit Processor based controller
• 8kHz servo loop update rates
• Miniature load cells available from 0.001N to 5N
• Load and Strain accuracy ± 0.5% of read out value
• 0-1.0 KHz data acquisition rates

• Mechanobiology investigations
• Uniaxial mechanical stimulation of cells
• Long period study of cell/matrix interaction at high magnification
• The process of fibroblasts populating, growing to confluence and stratifying on different substrates
• Complex and organized cell sheet motions
• Coordinated extracellular matrix production