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Anhydrous aluminium chloride is the principal catalyst used in the Friedel-Crafts reaction, both acylations and alkylations. The product also finds application in the manufacture of Ibuprofen and other bulk drugs, ethyl benzene, isopropyl benzene, titanium dioxide, hydrocarbon resins, terpene resins and polybutenes.
The Friedel-Crafts reactions are used, for example, in the preparation of anthraquinone for the dyestuffs industry (phthalo-cyanine blues and greens) from benzene and phosgene.