Listing ID #3822163
Company Information
Ask for more detail from the seller
Contact Supplier
bortezomib (ps-341) is a potent 20s proteasome inhibitor with ki of 0.6 nm. It exhibits favorable selectivity towards tumor cells over normal cells.
bortezomib, a boronic acid dipeptide, is a highly selective, reversible inhibitor of the 26s proteasome which primarily functions in the degradation of mis-folded proteins and is essential for the regulation of the cell cycle. Exposure to bortezomib has been shown to stabilizebortezomib also promotes the activation of the proapoptotic c-jun-nh2 terminal kinase, as well as the endoplasmic reticulum stress response. Alteration of the levels of these cellular proteins leads to inhibition of proliferation, migration, and promotion of apoptosis of cancer cells. bortezomib is shown to penetrate into cells and inhibit proteasome-mediated intracellular proteolysis of long-lived proteins with a concentration that inhibits 50% of the proteolysis of 0.1 m. The average growth inhibition of 50% value for bortezomib across the entire panel of 60 cancer cell lines derived from multiple human tumors from the us national cancer institute ) is 7 nm. Treatment of pc-3 cells with bortezomib (100 nm) for 8 h results in the accumulation of cells in g2-m, with a corresponding decrease in the number of cells in g1. Bortezomib kills pc-3 cells at 24 and 48 hr with ic50 of 100 and 20 nm, respectively. Bortezomib induces nuclear condensation at 16–24 hr after treatment. Bortezomib treatment leads to parp cleavage in a time-dependent manner with concentrations as low as 100 nm being effective at 24 hr.
Nature of Business
Manufacturer / Exporter / Service Provider / Supplier / Retailer / Distributor / Importer / Trader / Buying House
Number of Employees
50 - 100
Year of Establishment
2001
Connect with us
For Buyer 
For Seller 
Help 
