Listing ID #1709008
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Contact SupplierWe are offering raloxifene hydrochloride.
Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (serm) used to prevent osteoporosis in postmeno- pausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
Raloxifene hydrochloride is the hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (serm) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast and endometrium. A resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type it promotes or suppresses the transcription of estrogen-regulated genes thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and ldl cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer.
synonyms: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy) phenyl] methanone; hydrochloride
cas number: 82640-04-8, mol. Formula: c28h28clno4s, mol.weight: 510.04
raloxifene hydrochloride is a light-yellow solid powder. It is soluble in dmso (50 mm), methanol, and ethanol (