Rosuvastatin Calcium, Form : Powder, Color : White

Listing ID #1659803

Rosuvastatin Calcium Is The Calcium Salt Form Of Rosuvastatin, A Statin With Antilipidemic Activity. Rosuvastatin Selectively And Competitively Binds To And Inhibits Hepatic Hydroxymethyl-glutaryl Coenzyme A (Hmg-coa) Reductase, The Enzyme Which Catalyzes The Conversion Of Hmg-coa To Mevalonate, A Precursor Of Cholesterol. This Leads To A Decrease In Hepatic Cholesterol Levels And Increase In Uptake Of Ldl Cholesterol. It Is Synthetic Lipid Lowering Agent & In Addition To Anti-atherosclerotic Benefit, It Also Exhibits Anti-inflammatory, Cardioprotective And Anti-platelet Activities. Separately, Rosuvastatin Down Regulates Erk, P38mapk, Matrix Metalloproteinases 2 And 9 (Mmp2/9), And Pai Expression, Inhibiting Migration And Proliferation Of Vascular Smooth Muscle Cells. Additionally, Rosuvastatin Inhibits Activation Of Nadph Oxidase And Pkc, Decreasing Platelet Recruitment And Activation In Vitro And Ex Vivo.
Details

• Synonyms - Calcium,(E,3r,5s)-7-[4-(4-fluorophenyl)-2-[methyl(Methyl Sulfo- Nyl) Amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
• Cas Number - 147098-20-2
• Mol. Formula - C44h54caf2n6o12s2
• Mol.weight - 1001.13
• It Is White Crystalline Powder With Melting Point 155 °c. Sparinglysoluble In Water & Methanol And Slightly Soluble In Ethanol
• Standard - Offered Of Pharmaceutical Grade BP/USP/EP
• Packing - Offered In Export Worthy Packing Of 5/25 Kilos Or As Per Our Customer Requirements