AdvantaPure, Div. of NewAge Industries, Inc.

An alternative for sanitary connections is now available from AdvantaPure...Overmolded Tri-Clamp Ends for PVC, TPE, and TPR tubing and hose. Injection molded from USP Class VI Hytrel or polypropylene, Overmolded Tri-Clamp Ends feature Tri-Clamp and mini Tri-Clamp styles up to 1-12". Overmolded Tri-Clamp Ends greatly reduce bioburden entrapment situations associated with barb-type fittings. They cost less than silicone counterparts, making them an attractive option for pharmaceutical, medical, surgical, food, beverage, and dairy applications. KEY FEATURES Injection molded from USP Class VI Hytrel and polypropylene materials Certified free of animal-derived ingredients Ends are permanently attached using a thermal process — no leachable adhesives are involved Smooth interior for excellent flow and performance Reduces entrapment issues Provides a sanitary connection for thermoplastic tubing and hose Excellent component for single-use applications Less costly than similar components of silicone Available in both Tri-Clamp and mini Tri-Clamp Sizes range from mini through 1-12" Tri-Clamp Easily sterilizedcleaned Hytrel molds directly to PVC; polypropylene molds directly to TPR and TPE tubing such as AdvantaFlex® Assemblies made to order Documented quality control

Clear identification, cleanliness, sterilizability, and permanence are offered with AdvantaPure's AdvantaLABEL® tagging system. AdvantaLabel eliminates the issues involved with old-style metal, plastic, or even paper tags. Since the label is sealed to the hose in clean silicone, it can be either steam sterilized (SIP) or chemically cleaned (CIP) many times without degradation of the label. AdvantaLABEL is custom configured to meet your specific needs – part number, manufactured date, planned replacement date, or any specific information you deem critical. Contact your AdvantaPure® representative today to see how AdvantaLABEL can solve your hose tagging needs at 1-888-755-4370.O.D. mounted to reinforced silicone hoses – does not contact material flow Permanently vulcanized silicone Certified free of animal-derived ingredients Easy to read – label remains bright white after repeated sterilization Autoclavable Zero entrapment Handles clean-in-place (CIP) or steam-in-place (SIP) processes Customer supplied text is application specific Add color striping for quick line identification – 10 standard colors available* Field installation methods available

Eliminate production stoppages for sterilization, reduce the risk of contamination, and increase efficiency by incorporating Single-Use Systems from AdvantaPure. Single Use Systems, or SUS, simplify cleaning validations—use once and discard. Each system is custom made using platinum-cured, Class VI silicone tubing and hose or AdvantaFlex® Class VI biopharmaceutical grade tubing. Add fittings, stoppers and container closures, filters, bottles, labels and tracking options, and other components. Custom manufactured and assembled from a variety of components Reduces end-user assembly labor expense and time Reduces cross contamination risks Saves energy and resource costs by eliminating cleaning and autoclaving Reduces production downtime by eliminating certain cleaning validation requirements Provides flexibility and speed in facility design—system redesigns are implemented faster than with hard piping Less costly process development and design compared to systems of hard piping Assembled and packaged in Class 7 (Class 10, 000) ISO-certified clean rooms Available with validated sterility assurance of 10-6 per ISO 11137 method VDmax 25 Documented lot traceable with identification on bags Documented quality control Experienced engineers available for technical assistance Tubing and molded connections provide a single, animal-derived ingredient-free material contact surface Complete validation package available upon request Optional RFID tags easily attach to assemblies for identification purposes—provide reliable electronic data storage and current status of assemblies from inception to disposal The silicone and thermoplastic elastomer compounds used to make Single-Use Systems have a Master File with the U.S. Food and Drug Administration

Manufactured from USP Class VI, platinum-cured silicone elastomer or from AdvantaFlex® biopharmaceutical grade TPE, AdvantaPure's BioClosure Systems offer the utmost in purity. They're biologically safe and work with vessels of glass, metal or plastic. Stoppers, caps, inserts for True Unions and GL45's, and other styles, with or without tubing, are available. Ideally suited for pharmaceutical, biotech, and laboratory environments Silicone elastomer meets USP Class VI, FDA CFR 177.2600, ISO 10993, European Pharmacopoeia 3.1.9, and other industry standards Assembled and packaged in a Class 7 (Class 10, 000) ISO-certified clean room Both silicone and TPE are certified free of animal-derived ingredients Documented lot traceable For single or repeated use – sterilizable through autoclave or gamma radiation Single use applications reduce cleaning and validation requirements and costs, plus cross contamination risks Smooth, gap-free surfaces for a true seal and a secure environment Longer life expectancy, more consistent performance, and higher purity than parts made from rubber materials Resistant to cracking and particle migration No taste or odor transfer Excellent chemical resistance properties Silicone withstands temperatures ranging between -100°F (-73.3°C) and 400°F (204.4°C) Select stopper sizes available; other silicone closures custom manufactured Certain styles available manufactured from AdvantaFlex® biopharmaceutical grade TPE (thermoplastic elastomer) For use with flexible container systems, laboratory apparatus and bottles, and sampling and storage receptacles of glass, plastics, or metal Available with tubing installed Validation and extractables test portfolios available upon request The silicone and thermoplastic elastomer compounds used to make BioClosure Systems have a Master File with the U.S. Food and Drug Administration AdvantaPure's BioClosure Systems are manufactured from pure silicone or TPE that's free of animal-derived components. Your processes stay biologically safe.

Supplied as silicone fittings attached directly to silicone tubing or hose, AdvantaPure's Molded Silicone Assemblies are well-suited for applications involving aseptic transfer, sterile processing, and other critical applications in the pharmaceutical, biomedical, and high purity industries. The assemblies reduce installation time, improve cleanliness, and retain the many benefits of silicone. Eliminates entrapment issues and leaks associated with barb-type fittings Provides a smooth inner surface with a seamless transition Offers consistent interior dimensions for maximum flow rates Reduces end-user assembly times—arrives ready to install No product contact with metallic materials Retains silicone's temperature resistance: -100°F to 400°F Extremely flexible Sterilizable by CIP, SIP, and autoclave processes Certified free of animal-derived ingredients Imparts no taste or odor to critical streams Cleanroom manufactured Sealed in clear polybags during manufacturing process to ensure cleanliness Documented lot traceable with identification on bags Documented quality control The compound used to make Molded Silicone Assemblies has a Master File with the U.S. Food and Drug Administration

Class VI, platinum-cured silicone elastomer comprises AdvantaPure's peristaltic pump grade silicone tubing. Ideally suited for pharmaceutical, biotech, and laboratory environments, APSPG is specially formulated to withstand repeated compression and release for consistent, dependable performance and far outlasts standard silicone tubing. APSPG platinum cured pump tubing has undergone extensive physical, chemical, and biological testing, and meets USP Class VI, FDA CFR 177.2600, ISO 10993, and European Pharmacopoeia 3.1.9 standards. APSPG Pump Grade Silicone Tubing is not intended for implantation, continuous steam applications, or elevated pressure levels. Special formulation promotes long life in pumps Extremely flexible and resilient; hardness value of 50 Shore A Outstanding compression characteristics Smooth surfaces offer uniform fluid flow, resistance to bacteria build-up, and consistent pump performance APSPG tubing is USP Class VI approved Material meets FDA 21 CFR 177.2600 Certified free of animal-derived ingredients Low volatile grade suitable for pharmaceutical and biopharm applications Maximum operating temperature: 400°F (204.4°C); brittle temperature: less than -100°F (-73.3°C) Sterilizableautoclavable Imparts no taste or odor to critical streams Translucent for visual contact with the flow Stocked in sizes from .031" through .500" I.D. Supplied double bagged Documented lot traceable with identification on bags Documented quality control

Low volatile grade, platinum-cured silicone hose is clean room produced for critical pharmaceutical, biopharm, cosmetic, and food applications. Polyester yarn braiding inside the wall enhances the pressure capabilities. APSH has undergone extensive physical, chemical, and biological testing and meets USP Class VI, FDA CFR 177.2600, ISO 10993, European Pharmacopoeia 3.1.9, and 3-A standards. APSH Braid-Reinforced Silicone Hose is not intended for implantation and is not to be used for continuous steam applications.Hardness value of 65 Shore A (validatable liner: 70A; cover: 60A) Extremely flexible General temperature range: -100° F (-73.3° C) to 400° F (204.4° C) Sterilizable by autoclave, CIP, SIP, and gamma radiation processes Low volatile grade suitable for pharmaceutical and biopharm applications Listed by the National Sanitation Foundation for food equipment materials (NSF-51) Certified free of animal-derived ingredients Resists temperature extremes, compression set, chemical attack, ozone, radiation, moisture, and environmental exposure Imparts no taste or odor to critical streams Stocked in 25 and 50 ft. coils Documented lot traceable with identification on bags Documented quality control Complete validation package available upon request Color tracer braid available for easy identification Supplied double bagged; other packaging options available Custom lengths, sizes, andor special cleaning available APSH has a Master File with the U.S. Food and Drug Administration (#27582)

• Minimum Bend Radius(in.)3.0 , (mm)76.2
• Weight per Foot(lbs.).08

• Working Pressure(PSI) 450 , (Bar) 32
• Bend Radius(in.)2 , (mm)66
• Weight Per Ft.(lbs.).46

• Weight Per Ft.(lbs.).32
• Minimum Bend Radius(in.)1.5 , (mm)38.1