Biochempharmaltd

Baytown, United States

ANTI AGE (Botulinum Toxin Type A for Therapy) is the sterile, lyophilized exotoxin of Cloristidium Botulinum.

ANTI AGE (Botulinum Toxin Type A for Therapy) is the sterile, lyophilized exotoxin of Cloristidium Botulinum. It is a dichain polypeptide molecule consisting of a 50-kD light chain and 100-kD heavy chain linked by disulfide bonding. It is grown in a medium containing trypticase and yeast extract. A series of purifying procedure were taken to form a crystalline complex. After re-dissolved and dialyzed the crystalline toxin, an accurate amount of sterile filtered (0.2 microns) toxin were added to a solution containing albumim-dextran-mannitol-NaCl, the lyophilized.

Each vial of ANTI AGE contains 100 or 50 units (IU) of Cloristidium Botulinum Toxin Type A, 0.5mg human albumin, 30mg dextran, 30mg mannitol and 0.9mg NaCl. Dilute with non-pyrogen and sterile normal saline according to different needs before using. The white loose powder turns to be colorless or yellowish transparent solution after the reconstitution.

One unit (IU) of ANTI AGE corresponds to 1 LD50 of Botulinum Toxin type A while being intraperitoneally injected into mouse.

ANTI AGE could block neuromuscular conduction by inhibiting the release of acetylcholine and therefore causes local muscle flaccid paralysis.

INDICATIONS

ANTI AGE is indicated for:

1.Treatment of blepharospasm, hemi facial spasm in adults and some type of strabismus, especially for acute paralytic strabismus, comitant strabismus, strabismus caused by endocrine myopathy and strabismus.

2.Hyperhidrosis.

3.Cosmetic use.

USAGE AND DOSAGE

1.Position for injection.

a)For blepharospasm, injection should be given intramuscularly at several points of upper and lower lids, i.e., taking 4 or 5 points of injection into orbicular is oculi of medial and lateral or lateral Canthus temporal.