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Astringents like Periwinkle are also used by herbalists to soothe gastrointestinal distress and to support venous health.
What is the recommended dosage?
There is no recent clinical evidence to support specific doses of periwinkle herb. The pure alkaloids vincristine and vinblastine are used in cancer therapy at single weekly IV doses of 0.05 to 0.15 mg/kg and 0.1 to 0.2 mg/kg respectively.
Pregnancy/Lactation
Information regarding safety and efficacy in pregnancy and lactation is lacking. Avoid use.
Side Effects
Do not self-administer the plant periwinkle. Physicians will inform patients using pharmaceutical forms of periwinkle of possible adverse reactions.