Beijing Mediking Biopharm

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Systematic (IUPAC) name：RS)-benzyl N-[3-(acetylthio)-2-benzylpropanoyl]glycinate CAS number：81110-73-8 Formula：C21H23NO4S Mol. mass：385.47662 g/mol Racecadotril, also known as acetorphan, is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor. Unlike other medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine. It is available in France (where it was first introduced in 1993 and is widely used) and other European countries, as well as most of South America and some South East Asian countries, but not in the United States. It is sold under the tradenames Hidrasec or, in France, Tiorfan. In Italy it is sold under the tradename Tiorfix. A small randomized controlled trial found racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy. Thiorphan is the active metabolite of racecadotril.

Trospium chloride (INN) is a urinary antispasmodic. Trospium chloride is a quaternary ammonium compound, which is a competitive antagonist at muscarinic cholinergic receptors. Preclinical studies using porcine and human detrusor muscle strips demonstrated that trospium chloride was many-fold more potent than oxybutynin and tolterodine in inhibiting contractile responses to carbachol and electrical stimulation. The drug is poorly bioavailable orally ( It has been developed and patented by Robert Pfleger (Germany) and is sold under the brand name Sanctura in the US, Trosec in Canada, Regurin and Flotros in the United Kingdom and Spasmex in Germany, Russia, Turkey, Argentina, Chile and Israel. The drug is used for the treatment of Overactive Bladder.