Apsolabs Private Limited

Naubasta, Kanpur, Uttar Pradesh

Salt Composition

• N acetylcysteine 250 Mg
• Pyridoxin Hydrochloride: -50 Mg
• Ascorbic Acid (Vitamin C): - 75 Mg
• Vitamin E: - 200 IU
• Vitamin A: - 900 IU
• Zinc: - 8 Mg
• Folic Acid; - 5 Mg

Introduction: Tuberculosis Challenges: Ahead

• As per the Global TB report 2017 the estimated incidence of TB in India was approximately 28, 00, 000 accounting for about a quarter of the world’s TB cases.
• India continues to have the highest number of tuberculosis (TB) cases in the world
• Tuberculosis is probably associated with more severe malnutrition than other chronic illnesses
• A less than ideal weight gain during TB treatment also increases the risk of long-term relapse even after initial cure. Under nutrition has also been associated with malabsorption of key anti TB drugs.
• Majority of TB patients notified are from the age group of 15-45 years and they are from the lower socio-economic strata of the society.
• Also, since they are from working group age, TB disease affects the income of the family also while patients are on care.
• There is increasing evidence that under nutrition in patients with active TB is associated with an increased frequency and severity of disease and indeed a two-to-four-fold increase in mortality. There is also a fivefold risk of drug induced liver damage.
• Peripheral neuropathy is a well-known adverse effect of Isoniazid.
• Anti-tuberculosis drug-induced liver injury (TB DILI) is a leading cause of DILI and drug-induced acute liver failure (DIALF) in India and much of the developing world.
• Marked oxidative stresses were seen in the TB population as compared to the healthy cohort.
• 20% of patients develop asymptomatic elevation of liver enzymes which is self-limiting (as a result of adaptation or discontinuance) in a majority of patients (1)
• Anorexia is also a contributing factor for wasting in tuberculosis.
• Malnourished tuberculosis patients have delayed recovery and higher mortality rates than well-nourished patients. (8)
• TB and under nutrition can cause a vicious cycle of worsening disease and under nutrition.

• Disease: Increased severity & higher mortality
• Treatment: Increased adverse effects (liver toxicity), malabsorption of drugs such as rifampicin, increased relapse after cure, delayed sputum conversion
• TB transmission in household: Increased risk of TB incidence in undernourished contacts.

TB Nutritional Care & Support

In more developed countries, only a few people with TB will need nutritional care & support as part of their TB treatment and care. In other countries, such as India, the majority of people with TB may need nutritional care & support. There are a number of principles for providing nutritional care and support as a necessary part of TB care and prevention and these include.

• When under nutrition is identified at the time of TB diagnosis, TB must be considered a key cause that needs to be addressed.
• An adequate diet is necessary for the well-being and health of all people,  including those with TB infection or TB disease.
• Because of the clear two-way link between under nutrition and active TB, nutritional assessment and counselling are vital parts of TB treatment and care.
• Poverty and food insecurity are both causes and consequences of TB, and those involved in TB care therefore play an important role in recognizing and addressing these wider socioeconomic issues.
• TB is commonly accompanied by co-morbidities such as HIV, diabetes, smoking and alcohol or substance abuse, which has their own nutritional implications and these, should be fully considered during nutrition assessment and counselling.

N-Acetylcysteine (NAC) 250 Mg: -

• Protective effects seen in Anti-TB drug induced hepatotoxicity.
• The Antioxidant role of glutathione supplements seen in reducing oxidative stress
• Nac is strong mucolytic and helps in expectoration

Pyridoxin HCL:-

• Prevent the development of peripheral neuropathy caused by Isoniazid  

Ascorbic Acid: -

• Washington, DC – January 3, 2018 – Studies in mice and in tissue cultures suggest that giving vitamin C with tuberculosis drugs could reduce the unusually long time it takes these drugs to eradicate this pathogen.

Vitamin E: -

• Currently, micronutrient deficiencies are thought to be the most common cause of secondary   immunodeficiency and the most prominent risk factor for infection-related morbidity, which potentially affect individuals’ susceptibility to tuberculosis and may alter the natural course of this disease (4).

Zinc & Vitamin A

• "The effectiveness of anti-tuberculosis treatment was improved during the first two months by vitamin A and zinc supplementation, " Dr. Clive E. West, a professor in the department of nutrition at Wageningen University in the Netherlands, and colleagues write in the April issue of the American Journal of Clinical Nutrition (2002;75:720-727).

Apsoclav LB 625 Tablet is a penicillin-type of antibiotic that helps your body fight infections caused by bacteria. It is used to treat infections of the lungs (e.g., pneumonia), ear, nasal sinus, urinary tract, skin and soft tissue. It will not work for viral infections such as the common cold.

Apsoclav LB 625 Tablet is best taken with a meal to reduce the chance of a stomach upset. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back or worsen.

The most common side effects of this medicine include vomiting, nausea, and diarrhea. These are usually mild but let your doctor know if they bother you or will not go away.

Before taking it, let your doctor know if you are allergic to any antibiotics or have any kidney or liver problems. You should also let your healthcare team know about all other medicines you are taking as they may affect, or be affected by, this medicine. This medicine is generally regarded as safe to use during pregnancy and breastfeeding if prescribed by a doctor.

Uses

Bacterial infections

Benefits

In Bacterial infections

Apsoclav LB 625 Tablet contains two different medicines, Amoxycillin and Clavulanic Acid, that work together to kill the bacteria that cause infections. Amoxycillin works by stopping the growth of bacteria. Clavulanic Acid reduces resistance and enhances the activity of Amoxycillin against bacteria.

This combination medicine can be used to treat many different bacterial infections such as ear, sinus, throat, lung, urinary tract, skin, teeth, joints, and bones. It usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.

Side Effects

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Apsoclav LB 625

Vomiting, Nausea, Diarrhoea

How to Use

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Apsoclav LB 625 Tablet is to be taken with food.

How it Work

Apsoclav LB 625 Tablet is a combination of two medicines: Amoxycillin and Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Amoxycillin against bacteria.

Safety Advice

Warnings: Alcohol

SAFE

Consuming alcohol with Apsoclav LB 625 Tablet does not cause any harmful side effects.

Warnings: Pregnancy

SAFE IF PRESCRIBED

Apsoclav LB 625 Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Warnings: Breast feeding

SAFE IF PRESCRIBED

Apsoclav LB 625 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Warnings: Driving

UNSAFE

Apsoclav LB 625 Tablet may cause side effects which could affect your ability to drive.

Apsoclav LB 625 Tablet may cause side effects such as allergic reactions, dizziness or fits that may make you unfit to drive.

Warnings: Kidney

CAUTION

Apsoclav LB 625 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Apsoclav LB 625 Tablet may be needed. Please consult your doctor.

Use of this medicine is not recommended in patients with severe kidney disease.

Warnings: Liver

CAUTION

• Apsoclav LB 625 Tablet should be used with caution in patients with liver disease. Dose adjustment of Apsoclav LB 625 Tablet may be needed. Please consult your doctor.
• Regular monitoring of liver function tests is recommended while you are taking this medicine

What if you forget to take Apsoclav Lb 625 Tablet

If you miss a dose of Apsoclav LB 625 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Apsovent Expectorant Green Apple Sugar Free is used in the treatment of cough with mucus. It loosens and thins mucus in the nose, windpipe, and lungs. This makes it easier for you to cough it out. It also relaxes and widens the muscles in the airways making it easier for you to breathe.

Apsovent Expectorant Green Apple Sugar Free is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are nausea, vomiting, diarrhea, stomach pain, upset stomach, headache, rash, palpitations, tremor, and increased heart rate. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine can also cause sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can make sleepiness worse.

Never support self-medication or recommend your medicine to another person. It is beneficial to have plenty of fluids while taking this medication. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you.

Uses

Cough with mucus

Benefits

In Cough with mucus

Apsovent Expectorant Green Apple Sugar Free gives relief from cough with mucus. It helps to loosen thick mucus, reduce its stickiness and makes it easier to cough out. This makes breathing easy and reduces the frequency of coughing. Apsovent Expectorant Green Apple Sugar Free will also relieve allergy symptoms like watery eyes, sneezing, runny nose or throat irritation. Along with medications, drink enough Luke warm water and gargle with warm salt water to ease the symptoms.

Side Effects

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of APSOVENT SYRUP

Nausea, Vomiting, Diarrhea, Stomach pain, Upset stomach, Dizziness, Headache, Rash, Allergic, reaction, Hives, Palpitations, Tremor, Increased heart rate

Ho to Use

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Apsovent Expectorant Green Apple Sugar Free may be taken with or without food, but it is better to take it at a fixed time.

How it Work

Apsovent Expectorant Green Apple Sugar Free is a combination of three medicines: Ambroxol, Guaifenesin and Terbutaline, which relieves cough with mucus. Ambroxol is a mucolytic which thins and loosens mucus (phlegm), making it easier to cough out. Guaifenesin is an expectorant which decreases the stickiness of mucus (phlegm) and helps in its removal from the airways. Terbutaline is a bronchodilator. It works by relaxing the muscles in the airways and widens the airways. Together, they make breathing easier.

SAFETY ADVICE

Warnings: Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Apsovent Expectorant Green Apple Sugar Free. Please consult your doctor.

Warnings: Pregnancy

CONSULT YOUR DOCTOR

Apsovent Expectorant Green Apple Sugar Free may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Warnings: Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Apsovent Expectorant Green Apple Sugar Free during breastfeeding is not available. Please consult your doctor.

Warnings: Driving

UNSAFE

Apsovent Expectorant Green Apple Sugar Free may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Warnings: Kidney

CAUTION

Apsovent Expectorant Green Apple Sugar Free should be used with caution in patients with kidney disease. Dose adjustment of Apsovent Expectorant Green Apple Sugar Free may be needed. Please consult your doctor.

Warnings: Liver

CAUTION

• Apsovent Expectorant Green Apple Sugar Free should be used with caution in patients with liver disease. Dose adjustment of Apsovent Expectorant Green Apple Sugar Free may be needed. Please consult your doctor.
• Limited information is available on the use of Apsovent Expectorant Green Apple Sugar Free in these patients.

What if You Forget to Take Apsovent Syrup?

If you miss a dose of Apsovent Expectorant Green Apple Sugar Free, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.