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How to use Amlodipine Oral :

• Take this medication by mouth with or without food as directed by your doctor, usually once daily. Take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. If used for angina, this medication must be taken regularly to be effective. It should not be used to treat angina when it occurs.
• This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Precaution : Before using this medication, tell your doctor your medical history, especially of: a certain structural heart problem (aortic stenosis), very low blood pressure, liver .

Drug interaction :

• Co-administration of multiple doses of 10 mg of amlodipine with 80 mg resulted in a 77% increase in exposure to compared to alone. Limit the dose of .
• Co-administration of a 180 mg daily dose of with 5 mg amlodipine in elderlyhypertensive patients resulted in a 60% increase in amlodipine systemic exposure , Itraconazole, may increase the plasma concentrations of amlodipine to a greater extent.
• While using hypotensive and vasodilator effects may be reduced. May need to stop if BP control or renal function deteriorates. A lower dosage of may avoid this interaction.
• Tizanidin May cause severe hypotension. Monitor BP. Trimethoprim: May result in cardial arrest. Elderly patients with renal impairment or patients on high-dose Trimethoprim are at increased risk.

Side Effects :

• Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as feeling like you might pass out swelling in your hands, ankles, or feet, pounding heartbeats or fluttering in your chest or chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling. Headache dizziness , anxiety, fatigue, insomnia; nervousness; tremor. Abdominal pain, constipation, diarrhea, dry mouth, back pain, cramps , muscle cramps , musculoskeletal pain, confusion, numbness or tingling in the hands, feet, or lips, shortness of breath, swelling of the ankles, feet, or lower legs

Pregnancy : There are no adequate and well-controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the risk to the fetus.

Nursing Mothers :  It is not known whether amlodipine is excreted in human milk. In the absence of this information, it is recommended that nursing be discontinued while Amlodipine is administered.

Storage :

• Store in cool dry and dark place.
• Keep all medicines out of reach of children.

Dosage : Temozolomide 20 mg, Temozolomide 100 mg, Temozolomide 250 mg

How it is Administered :

• The capsule should be swallowed whole with plenty of water.
• It should be taken timely everyday in an empty stomach.

Side Effects : Based on the resistance of the body and stage of the cancer, different people may react differently to the use of drug. Some may experience few side effects while other may experience more.

We have listed below few of the common side effect associated with Temozolomide :

• Lowered resistance to infection
• Bruising or bleeding
• Anaemia
• Nausea
• Diarrhoea
• Constipation
• Loss of appetite and temporary taste alterations
• Rashes
• Headache
• Tiredness and feeling weak

Precautions :

• Tell your doctor about the other medicines you are taking, including vitamins, herbal supplements and over the counter drugs.
• Take care while driving or operating the machineries, since the use of the drug may cause drowsiness.
• Discuss with your doctor, if you are planning to become pregnant or father of a child
• If you feel uneasy or sick after taking the medicine immediately inform your doctor, as you may not need another one. Do not take another without the recommendation of the doctor.
• If you forget to take a capsule do not take double dose. Consult you doctor and maintain a regular dose schedule.
• Store the capsules in a cool dry place in its original packaging, away from heat and sunlight.
• Keep the capsule in safe place away from reach of the children

How it is Administered : The capsule should be swallowed whole with the water.

Side Effects : The effect of the medicine differs from person to person based on resistance power and stage of the cancer.

The following are some of the side effects that are known to be associated with this medicine :

• Low blood count
• Tiredness Pale
• Skin Fever Sore throat
• Anorexia Hairloss

Precautions : Inform your doctor if you are allergic to hydroxyurea, or any of the inactive ingredients in the capsules.The medicine should not be taken during pregnancy as it poses potent risk to the fetusInform your doctor about all the prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products that you night be taking or plan to take. Inform your doctor in case you are breast-feeding as it is not recommended when the medicine is being taken.