PH40 grades are chemically castor oil derivatives. They consist hydrophobic and hydrophilic part. They are non-ionic solubilizes and emulsifying agents obtained by reacting hydrogenated castor oil with ethylene oxide. They are almost testless and orderless.
They are used as solublizer for fatsoluble perfumes, vitamins, essential oils and other hydrophobic pharmaceuticalslt improves the solubilify of poorly soluble drugs .They have ability to solublize or emulsify oil soluble ingredients and convert them into clear transparent solution or stable emulsion respectively.
Applications :
- Solubilizer: HCO range improves water solubility of major water insoluble products. It helps to solubilize different pharmaceutical active ingredients like Bromhexidine HCL, Dextromethorphan HBr, Acetaminophen, Povidone iodine, Loxapine Succinate, Vitamins like vitamins like vitamin Vitamin E acetate, A palmitate, vitamin D, etc. It is compatible with most of all ingredients. It is also used as solubilizer and stabilizer for oils and perfume in cosmetic industries.
- Aerosol Formulations: HCO improves solubility of the propellant in aerosol in aqueous phase.
- Transparency Improver: HCO rang solubilizes insoluble oily substances in aqueous system and hence it improves transparency and shining. In cosmetic formulation, it impacts elegance appearance of products such as shaving gel, hair styling gel, hand wash gel etc. In pharmaceutical syrup formulations, it improves transparency.
- Dissolution Improver: It should be mixed with API with or without heating and then dissolved in vehicle. It is generally used between 3.0% to 5.0% w/w of API to improve dissolution of poorly soluble active ingredients like Cefuroxime Axetil, Albendazole etc. HCO range is excellent versatile non-ionic emulsifying agent. It has an excellent emulsify ability, suitable for emulsification of mineral oil, natural oil, steary etc. it can obtain a steady system when used alone. It emulsifies major hydrophobic substances like fatty acids, fatty alcohols, mineral oil etc. it is suitable to obtain O/W cream and lotions, also can be used as stabilizer for skin care.
- Moisturizer: HCO range improves moisturizing effect and soft feeling.
- Masking Agent: HCO maska unpleasant taste and odour of typical formulations like pharmaceutical syrup containing alcohols and suspension like artemether and lumefantrine suspension.
- Volatility retardant: HCO range retards volatilities of solvents. It can be used for highly volatile products like after shaving lotion, perfumes etc. to retain its effect for longer period.
- Former: HCO is preferred in cream, lotion, lipstick etc. to improve film forming capacity. HCO range improves film forming capacity and flow properties.