Medicines Tonics And Drugs #3687625

Product Details:

• Usage:Hospital

Geftinat-Gefitinib
Specifications

• Content : Gefitinib 250mg
• Form : Tablets
• Strength : 250 mg
• Packing : Pack of 30 tablets
• Available as : 250 mg tablets
• Manufactured by : Natco

• Item Code:GeftinatTablets
• Port of Dispatch:New Delhi, India
• Delivery Time:As per the order
• Packaging Details:Pack of 30 tablets

Content : Gefitinib 250mg

Form : Tablets

Strength : 250 mg

Packing : Pack of 30 tablets

Available as : 250 mg tablets

Manufactured by : Natco

Amoxicillin/ clavulanic acid, also known as co-amoxiclav, is an antibiotic useful for the treatment of a number of bacterial infections. It is a combination consisting of amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. It is specifically used for otitis media,  strep throat,  pneumonia,  cellulitis,  urinary tract infections,  animal bites, and tuberculosis It is taken by mouth or by injection into a vein.
It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.

Medical uses :Amoxicillin/clavulanic Acid Is Widely Used To Treat Or Prevent Many Infections Caused By Susceptible Bacteria, Such As :

• Urinary Tract Infections
• Respiratory Tract Infections
• Skin And Soft Tissue Infections
• Sinus Infections
• Cat Scratches

• Infections Caused By The Bacterial Flora Of The Mouth, Such As :
  • Dental Infections
  • Infected Animal Bites
  • Infected Human Bites (Including Uncomplicated "Clenched-fist" Or "Reverse-bite" Injuries)

This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase.

Veterinary use :Amoxicillin/clavulanic Acid Is Used In Numerous Animals For A Variety Of Conditions :

• Dogs - Periodontitis, Kennel Cough
• Cats - Urinary Tract Infections, Skin And Soft Tissue Infections
• Calves - Enteritis, Navel Ill
• Cattle - Respiratory Tract Infections, Soft Tissue Infections, Metritis, Mastitis
• Pigs - Respiratory Tract Infections, Colibacillosis, Mastitis, Metritis, Agalactia

In combination with prednisolone, it is used for intramammary infusion for the treatment of mastitis in lactating cows. Trade names include Clavaseptin, Clavamox, and Synulox. Amoxicillin/clavulanic acid is banned from use in domestic-food animals (cattle, swine, etc.) in both the US and Europe; in the UK, Synulox can be used in domestic-food animals as long as a specified withdrawal period is observed.

Gliclazide, sold under the brand name Diamicron among others, is an anti-diabetic medication used to treat diabetes mellitus type 2.it is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth.
Side effect may include low blood sugar, vomiting,  dominal pain, rash, and liver problems. Use by those with significant kidney problems, liver problems, or who are pregnant is not recommended. Gliclazide is in the sulfonylurea family of medications. It works mostly by increasing the release of insulin.

Medical uses :Gliclazide is used for control of hyperglycemia in gliclazide-responsive diabetes mellitus of stable, mild, non-ketosis prone, type 2 diabetes. It is used when diabetes cannot be controlled by proper dietary management and exercise or when insulin therapy is not appropriate. National Kidney Foundation (2012 Update) claims that Gliclazide does not require dosage uptitration even in end stage kidney disease.

Mechanism of action :Gliclazide selectively binds to sulfonylurea receptors (SUR-1) on the surface of the pancreatic beta-cells. It was shown to provide cardiovascular protection as it does not bind to sulfonylurea receptors (SUR-2A) in the heart. This binding effectively closes the K+ ion channels. This decreases the efflux of potassium from the cell which leads to the depolarization of the cell. This causes voltage dependent Ca++ ion channels to open increasing the Ca++ influx. The calcium can then bind to and activate calmodulin which in turn leads to exocytosis of insulin vesicles leading to insulin releas The mouse model of MODY diabetes suggested that the reduced gliclazide clearance stands behind their therapeutic success in human MODY patients, but Urbanova et al. found that human MODY patients respond differently and that there was no consistent decrease in gliclazide clearance in randomly selected HNF1A-MODY and HNF4A-MODY patients. Its classification has been ambiguous, as literature uses it as both a first-generation  and second-generation sulfonylurea.

Metabolism :Gliclazide undergoes extensive metabolism to several inactive metabolites in human beings, mainly methylhydroxygliclazide and carboxygliclazide. CYP2C9 is involved in the formation of hydroxygliclazide in human liver microsomes and in a panel of recombinant human P450s in vitro. But the pharmacokinetics of gliclazide MR are affected mainly by CYP2C19 genetic polymorphism instead of CYP2C9 genetic polymorphism.

Average Price : 850 for 100 Tablet.

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