Phenethylamine, or phenylethylamine is an organic compound and a natural monoamine alkaloid, a trace amine, and also the name of a class of chemicals with many members that are well known for their psychoactive and stimulant effects.Phenylethylamine functions as a neuromodulator or neurotransmitter in the mammalian central nervous system. It is biosynthesized from the amino acid l-phenylalanine by enzymatic decarboxylation via the enzyme aromatic l-amino acid decarboxylase. In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after microbial fermentation. It is sold as a dietary supplement for purported mood and weight loss-related therapeutic benefits; however, orally ingested phenethylamine experiences extensive first-pass metabolism by monoamine oxidase b (mao-b), which turns it into phenylacetic acid. This prevents significant concentrations from reaching the brain when taken in low doses.
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Shirish Mody (JB Chemicals & Pharmaceuticals Ltd)
Neelam Centre B-Wing 4/F Hind Cycle Road Worli, Mumbai, 400030 India, Maharashtra
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