Global Fields - Anti Diabetic Drugs

Metformin HydrochlorideSynonyms:1, 1-Dimethylbiguanide hydrochloride;1, 1-dimethyl-biguanidhydrochloride;diabefagos;diformin;dimethylbiguanidehydrochloride;Dimethyldiguanidinehydrochloride;gliformin;haurymellinCAS:1115-70-4MF:C4H12ClN5MW:165.62EINECS:214-230-6Melting point:223-226 C(lit.)Water Solubility:Soluble in water (50 mgml), ethanol, and DMSO (50 mM)Chemical Properties:White crystal or crystalline powder. Melting point 232 (218-220 ). Soluble in water, dissolved in methanol, slightly soluble in ethanol, insoluble in ether and chloroform. Odorless, bitter taste.Application The product belongs to hypoglycemic agents. It can be used in patients with type diabetes to reduce fasting and postprandial hyperglycemia, HbAlc can be decreased by 1% to 2%, hypoglycemic mechanism of this product may be: I increase the sensitivity of peripheral tissues to insulin, increases insulin-mediated glucose utilization . increase glucose utilization of non-insulin dependent tissues, such as brain, blood cells, kidney medulla, intestine, skin and the like. inhibit hepatic gluconeogenesis effect, reduce hepatic glucose output. IV inhibit glucose uptake by intestinal cells.