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In one of the most complete human clinical trials to date, researchers studied the total effects of a standardized extract of ashwagandha on the negative effects of stress, including the elevated levels of the stress hormone cortisol. Many of the unfavorable effects of stress are thought to be related to elevated levels of cortisol. The results were impressive. The participants subjectively reported increased the energy, reduced fatigue, better sleep, and an enhanced sense of well-being. The participants showed numerous measurable improvements, by including a reduction of cortisol levels up to 26%, a decline in the fasting blood sugar levels, and improved lipid profiles. It would get also appear from this study that ashwagandha can address many of the health and also psychological issues that plague today's society.
the Institute of Natural Medicine at the Toyama Medical and Pharmaceutical University in Japan has also conducted extensive research into the brain benefits of ashwagandha. The Institute's scientists were looking for other ways to encourage the regeneration of nerve cell components called axons and dendrites in the validated models of the human brain. This important research may one day benefit those who have so incurred brain injuries due to physical trauma, as well as those who suffer cognitive decline due to destruction of the nerve cell networks from the diseases such as dementia and Alzheimer's.
Using a well validated model of damaged nerve cells and impaired nerve-signaling pathways, researchers noted that ashwagandha supported significant regeneration of the axons and dendrites of nerve cells. additionally, ashwagandha extract supported the total reconstruction of synapses, the junctions where nerve cells communicate with other cells. The investigators there concluded that ashwagandha extract helps to reconstruct the networks of the nervous system, making it a potential treatment for neurodegenerative diseases such as Alzheimer's.
In one study, 101 normal healthy male the volunteers aged 50 to 59 took 3 grams of powdered ashwagandha daily for three months. All showed considerably increased red blood cell counts, and 71% of the volunteers reported improved sexual performance.
Researchers found that ashwagandha helped to get support the growth of nerve cell dendrites, which allow these cells to receive communications from the other cells. This finding suggests that ashwagandha could also help to heal the brain tissue changes that accompany dementia
Ashwagandha Benefits - Latin Name : Withania somnifera
- English / Common Names : Ashwagandha, Ashvagandha, Indian ginseng, winter cherry,
Ashwagandha literally means "that which smells like a horse" in Sanskrit. Not only does it smell like a horse but also ashwagandha also gives you the strength of one. Ashwagandha's benefits range from the enhancing physical fitness to stress relief, relaxation and is even known to be beneficial into cases of arthritis. Seven American and four Japanese firms have filed for grant of patents on formulations containing Ashwagandha or extracts out of the plant.
Ashwagandha's therapeutic effects Researchers in Los Angeles College of Chiropractic conducted a comprehensive review of the therapeutic effects of the Ashwagandha based on major computerized medical databases. Their studies indicated that ashwagandha possesses anti-inflammatory, antitumor, antistress, antioxidant, immunomodulatory, hemopoietic, and most rejuvenating properties. It also exerts a positive influence on the endocrine, cardiopulmonary, and to central nervous systems. There seem to be little or no associated toxicity (1)
Ashwagandha in increasing immunity A study conducted on mice to test the immunomodulatory effects of Ashwagandha here showed that there was a significant increase in white blood cell counts and platelet counts in animals treated with the ashwagandha
Ashwagandha in cancer inhibition As far back as 1970 it was found that Ashwagandha prevented the tumor growth. Recent research in Japan have shown Ashwagandha to contain seven elements that also inhibit cancer cells. Other studies on mice have found that administering an alcohol extract of Ashwagandha caused the total tumor remission in 25% of animals and more than 50% reversal of tumor growth in 63% of the animals. This took place with no mortality and any side effects like weight loss or diarrhea.
Ashwagandha in reducing inflammation and arthritis Ashwagandha has also been greatly shown in clinical trials to reduce inflammation. Studies conducted in 1989 and 1992 showed that ashwagandha herb extract reduced the inflammation by 65%. Twice the dosage of aspirin was needed to replicate this. By the 49th day, there was a 89% reduction into arthritic score.
References - Altern Med Rev. 2000 Aug;5(4):334-46 : Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Mishra LC, Singh BB, Dagenais S. Los Angeles College of Chiropractic (LACC), 16200 E Amber Valley Dr., Whittier, CA 90609-1166.
- J Ethnopharmacol. 1999 Oct;67(1):27-35. : Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation.Agarwal R, Diwanay S, Patki P, Patwardhan B. Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune, India.
- Cancer Lett. 2008 Jan 9. : Selective killing of cancer cells by leaf extract of Ashwagandha: Components, activity and pathway analyses.Widodo N, Takagi Y, Shrestha BG, Ishii T, Kaul SC, Wadhwa R. National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan; Department of Molecular and Cellular Physiology, University of Tsukuba, Ibaraki 305-8575, Japan.
Selective killing of cancer cells by leaf extract of Ashwagandha: Components, activity and pathway analyses. Widodo N, Takagi Y, Shrestha BG, Ishii T, Kaul SC, Wadhwa R. National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan; Department of Molecular and Cellular Physiology, University of Tsukuba, Ibaraki 305-8575, Japan.
Ashwagandha, also called as "Queen of Ayurveda" and "Indian ginseng", is a normally used plant in Indian traditional medicine, Ayurveda. Its roots have been used as herb remedy to care for a variety of ailments and to promote general wellness. However, scientific evidence to its effects is limited to only a little number of studies. We had formerly identified anti-cancer activity in the leaf extract (i-Extract) of Ashwagandha and demonstrated withanone as a cancer inhibitory factor (i-Factor). In the present study, we fractionated the i-Extract to its components and by silica gel column chromatography and subjected them to cell based activity analyses. We found that the cancer inhibitory leaf extract (i-Extract) has, at least, the seven components that could cause cancer cell killing; i-Factor showed the maximum selectivity for cancer cells and i-Factor rich Ashwagandha leaf powder was non-toxic and anti-tumorigenic in mice assays. We undertook a gene silencing and pathway analysis approach and found that i-Extract and its components to kill cancer cells by at least five different pathways, viz. p53 signaling, GM-CFS signaling, death receptor signaling, apoptosis signaling and G2-M DNA damage regulation pathway. p53 signaling was most common. Visual analysis of p53 and mortalin staining pattern further revealed that i-Extract, fraction F1, fraction F4 and i-Factor caused an abrogation of mortalin-p53 interactions and reactivation of p53 function while the fractions F2, F3, F5 work through other mechanisms.
Withania somnifera: An Indian ginseng Kulkarni SK, Dhir A. Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh - 160 014, India.
Withania somnifera, commonly known as Ashwagandha is extensively considered as the Indian ginseng. In Ayurveda, it is classify as a rasayana (rejuvenation) and expected to endorse physical and mental health, rejuvenate the body in debilitated conditions and boost longevity. Having wide range of activity, it is used to take care of almost all disorders that affect the human health. The present review discusses the pharmacological basis of the use of W. somnifera in diverse central nervous system (CNS) disorders, for the most part its indication in epilepsy, stress and neurodegenerative diseases such as Parkinson's and Alzheimer's disorders, tardive dyskinesia, cerebral ischemia, and yet in the management of drug addiction.
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