Saikrishnaa Associates Thoothukudi, Tamil Nadu

Amphotericin b (fungilin, fungizone, abelcet, ambisome, fungisome, amphocil, amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. Its name originates from the chemical’s amphoteric properties. Two amphotericins, amphotericin a and amphotericin b are known, but only b is used clinically, because it is significantly more active in vivo. Amphotericin a is almost identical to amphotericin b (having a double c=c bond between the 27th and 28th carbons), but has little antifungal activity. Currently, the drug is available as plain amphotericin b, as a cholesteryl sulfate complex (abcd), as a lipid complex (ablc), and as a liposomal formulation (lamb). The latter formulations have been developed to improve tolerability for the patient, but may show considerably different pharmacokinetic characteristics compared to plain amphotericin b.

Atgam – atgam is a lymphocyte-selective immunosuppressant, prescribed for prevention of organ rejection during transplantation. It is also used in aplastic anemia. Indications: atgam is a lymphocyte-selective immunosuppressant, prescribed for prevention of organ rejection during transplantation. It is also used in aplastic anemia. contraindications: hypersensitivity. Dosage: for organ rejection- adult- the recommended dose is 10 to 30 mgkg of body weight daily. Child- the recommended dose is 5 to 25 mgkg daily.

Avonex (interferon beta-1a) is made from human proteins. Avonex is a medication manufactured by a biotechnological process from one of the naturally-occurring interferons. It is made up of exactly the same amino acids as the interferon beta found in the human body. Avonex is in a class of drugs known as immunomodulators, which work by acting on the immune system. Avonex is used to treat relapsing multiple sclerosis. Avonex may also be used for purposes not listed in this medication guide. Manufacturer: biogen idec. Packing: 1 vial.

Benzatropine (inn), also known as benztropine (usan, ban), is an anticholinergic marketed under the trade name cogentin which is used in the treatment of parkinson’s disease, parkinsonism, and dystonia.

Trabectedin (also known as ecteinascidin 743 or et-743) is an anti-tumor drug. It is sold by zeltia and johnson and johnson under the brand name yondelis. It is approved for use in europe, russia and south korea for the treatment of advanced soft tissue sarcoma. It is also undergoing clinical trials for the treatment of breast, prostate, and paediatric sarcomas. The european commission and the u.s. Food and drug administration (fda) have granted orphan drug status to trabectedin for soft tissue sarcomas and ovarian cancer.

Verteporfin (trade name visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.