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Hepatotoxicity. Unlike most first generation antihistamines, cyproheptadine has beenassociated with several instances of clinically apparent liver injury. The few cases that have been described had a time to onset of 1 to 6 weeks and a cholestatic or mixed pattern of liver enzyme elevations
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Packaging Details : After cyproheptadine was discontinued, the aggression ceased over the course of a few weeks. Although there are other causal explanations possible in this case, cyproheptadine seems the most likely cause of the violent behavior, especially in view of the literature on the relation between serotonin and aggression.
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