Antihypertensive Drugs

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Amlodipine Besylate

CAS No. 111470-99-6
Appearance White powder
Melting Point 199-201 ºC
Boiling Point 527.2 ºC at 760 mmHg
Flash Point 272.6 ºC
Solubility Slightly soluble in water; sparingly soluble in ethanol
Risk Codes 22-36/37/38-20/21/22
Safety Description 26-36

Synonyms : Amlodipine benzenesulfonate;Monopina;Amlodin;Norvas;3, 5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)- 1, 4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monobenzenesulfonate;3, 5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1, 4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate; Myodura;Amcard;Tensivask;Norvasc (TN);3, 5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1, 4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate;Amdipin;Amlogard;Norvask;Antacal;3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1, 4-dihydro-6-methyl-3, 5-pyridinedicarboxylate, monobenzenesulfonate;Terloc;Astudar;benzenesulfonic acid; ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1, 4-dihydropyridine-3, 5-dicarboxylate;Norvasc;Cordarene;Cardiorex;

Formula : C₂₀H₂₅ClN₂O₅.C₆H₆O₃S

Density : 1.227 g/cm³

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Cilnidipine

Min. Order (MOQ) 50 Kilogram
Application Clinical, Hospital
Dose/Strength (ex. 1 mg or 1ml) As per prescription
Molecular Weight 492.54
Melting Point 1050C to 1100C
Loss on drying Not more than 0.5 %
Chemical Name 1, 4-Dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-3, 5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-pheny
Molecular Formula C27H28N2O7
C.A.S No 132203-70-4
Appearance Light yellow crystalline powder
Solubility Practically insoluble in water, Sparingly soluble in ethanol
Heavy Metals Not more than 10 ppm
Ignited residue (Sulphated Ash) Not more than 0.1 % w/w
Assay ( On Dried Basis) Not less than 99.0% and not more than 102.0%.

Chemical Name : 1, 4-Dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-3, 5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester.

Physical & Chemical Properties : Light Yellow crystalline powder, Practically insoluble in water, Sparingly soluble in ethanol

USE : Cilnidipine (INN) is a calcium channel blocker. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved to come into market for the first time and used for high blood pressure treatment in 1995. Compared with other calcium antagonists. cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium antagonists. Cilnidipine is approved for use in Japan, China, India, Korea and some European countries.

Identification :

By IR : The transmission minima (absorption maxima) in the spectrum obtained with the substance to be examined correspond in position and relative size to those in the spectrum obtained with the Cilnidipine working standard.
By HPLC : The retention time of the major peak in the chromatogram of the sample preparation corresponds in that of the peak due to Cilnidipine in the chromatogram of the standard preparation, as obtained in Assay.

Related Substances (by HPLC) :