Amesto Pharmatech

Khodiyar Nagar, Ahmedabad, Gujarat

The Liquid Manufacturing Plants Are Ideal Tools For The Pharmaceutical Industry For The Production Of Oral Liquids. It Is Specially Designed To Take Care Of Two Critical Factors Which Directly Affect The Quality Of The Liquids. Minimum Manual Handling Of Liquid.Effective Cleanness During Manufacturing. Capacity Ranges From 50 L To 20, 000 L.Needless To Say, It Also Provides The Benefits Of The Effective Manpower Utilization.

• Sugar Melting Vessel
• Pre-filtration Unit
• Syrup Manufacturing Vessel
• Filtration Unit
• Storage Vessel
• Control Panel
• Product Piping
• Working Platform
• This System Consists Of A Closed Circuit Manufacturing Facility From Feeding Of Sugar / Water Phase To Loading The Liquid Filling Machine.
• The Sugar And Water, Are Load With Vacuum System Or By Mechanical System Or Manually.
• The Sugar Syrup Vessel Is Supplied With High Speed Stirrer & Electrical Heating (In Small Model) / Steam Heating Facility (In Bigger Size Model) .The Sugar Syrup Is Prepared At Required Temperature & Are Transferred To Manufacturing Vessel By Vacuum Or By Transfer Pump.
• The Product During Emulsion Formation Is Recalculated Through In-Line Homogenizer Or Liquid Transfer Pump.( Optional Facility )
• The Pump Also Discharges The Product In The Storage Vessel.
• The Storage Vessel Is Then Taken To The Filling Area (if It Is Small Capacity) And Is Connected To Again Liquid Transfer Pump. Or Storage Vessel Remains Fixed (In Bigger Size) & Pump Transfer The Liquids In The Float Tank Which Is Connected With Filling Machine.
• The Entire Plant Can Be Operated By Centralized Operating Panel By One Operator.

• The Plant Is Designed To Be Operated Only By One Operator And One Helper.
• All Material Transfers Are Done By Vacuum Or By Transfer Pumps.
• All The Vessels Are CGMP (paint Free Construction)
• The Gaskets Used Are Of Silicon (food Grade).
• All Contact Parts Are Of S.S. 304 Quality Material (SS316 Provided On Demand) & Finished To Class 4B (Mirror) Finish And Are Crevice Free.
• The Entry Of Stirrer & High Speed Emulsifier Are From Top. In-line Emulsifier (as Per Customer Choice) Provided On Demand.
• All Vessels Are Suitable For Internal Pressure Of 1 Kg. / Sq. Cm. And Hence Can Be Sterilized.
• All Pipes, Pipe Fittings And Valves Are Of SS304 / SS316 (as Per Customer Requirement) Seamless Quality, Internally Electro Polished, With Tri-clover Ended Joints. E

Operation:-

The Unfiltered Liquid Is Fed Into The Filter Under Positive Pressure, Where Liquid Travels In Downwards Direction And Finds Its Way Through Opening On Sides Of The Filter Plates.

As The Liquid Pressure Increases, The Filter Media Holds The Foreign Particles And Allows Only Clear Filtrate To Pass Through The Central Channel Formed By Interlocking Pressure Cups To The Outlet. Filtration Is Continued Until The Cake Holding Capacity Of The Unit Is Reached Or Until The Filtrate Rate Becomes Too Slow Owing To Cake Resistance.

The Vacuum Transfer Systemis Unique Dry Material Transfer System For Dust Free And Avoid To Human Touch. The Vacuum Transfer System Is Used In Pharmaceutical, Food, Agro Chemical, Sugar Industries And Chemical. The System Is Use Full For Inline Milling, Sifting, Blending, Loading And Unloading.
The Principle Of Vacuum Transfer Has Been Proven To Be A Better Way To Move Many Types Of Material And A Giant Step Over Manual Handling. The Technology Exists For Moving Virtually Any Material That Can Be Pulled Through A Hose Or Tube. The System Is Consisting Of Blower, Vacuum Receiver System With Filter, Cyclone Filter And Pipe.
The Vacuum Conveying Systems Designed Specifically For The Direct Charge Loading Of Blenders, Mixers, Sifter, Milling, Reactors Or Any Vessel Capable Of Withstanding A Vacuum. The Vacuum System Can Be Provided Mobile Type With Lifting Provision To Move One Room To Another Room For Loading And Loading Any Machine.

New Design Features:-

• Design Is CGMP - Current Good Manufacturing Practices Compliance.
• All Contact Parts AISI 316 & Non Contact Parts AISI 304.
• Capacity Available 100 Kg To 5000 Kg/hr.
• Can Be Used For Transfer Of Products Having Bulk Densities Up To 1.0gm/cc.
• Total Discharge No Retention.
• No Segregation Or Degradation Of Product.
• No Tool Required For Opening & Cleaning.
• Transfer Can Be Completely Automatic To Avoid The Manual Handling Of The Material
• Fully Automatic System, With Timing Controls And Automatic Air Blow Back System For Filter Cleaning.
• Vacuum Blower And Cyclone Filter Can Be Installed In Out Side Production Area.
• Avoids Product Waste, Loss And Contamination.
• Easy To Clean And Wash Of Contact Parts.
• Option For Inline Milling, Sifting With Blender And Loading Material To RMG, Tablet Press& Vessel.

Simplified Construction, Uniform Human Machine Interface

As Opposed To Tailor-made Granulation Lines, The Most Important Functions Of Online Granulation Are Installed By Default. The High Level Of Standardization Now Enables Us To Fulfill Customer Demands For A Complete And Quickly Available System At The Accustomed High Quality, Says Scholz. Thanks To The Easy Alignment Of Machine Components On Site, The Granulation Unit Can Be Installed Quickly And Easily. All Process And Cleaning Steps Can Be Controlled Via Recipes. The Operator Interface Is A 21-inch Touch Screen With User-friendly Navigation.

Smooth Product Flow Through Integrated Wet Mill

The Process For Manufacturing Pharmaceutical Granules Begins By Pneumatically Filling The High-shear Mixer. The Mixing Device Azestomix, Which Is Driven From Below, Mixes And Granulates The Active Ingredients And Excipients. The Highshear Mixer Is Emptied Via The Equally Newly Developed, Integrated Wet Mill.

Communication Between Mill And Azestoline Granualtion Ensures That Only As Much Product Is Emptied As The Mill Is Able To Process, Which Prevents The Mill From Clogging. A Pneumatic Transfer Pipe Subsequently Transfers The Wet Product To The Granulation Fluid Bed Module, Where It Is Dried Through The Inflow Of The Proven Disk Jet Distribution Plate. The Function Of Process Filters Is Crucial To Obtain High Yields: For This Reason, Bosch Has Developed A New Process Filter, Where The Elements Are Serially Cleaned With Compressed Air Pulses. At The End Of The Drying Process, The Product Is Emptied By A Dry Mill.

Apart From The High-shear Mixer, Granulation Can Also Take Place In The Fluid Bed By Using A Tangential Or Top Spray Process. GranuLean Is Available For A Containment Level Of Up To OEB3 (Operational Exposure Band). The Machine Remains Closed During Operation, While Inflatable Seals On The Product Containers Provide For An Optimum Draught Proofing. Moreover, The Integrated Cleaning System Ensures An Even Easier Handling.

Tablets And Capsules In Line

Suitable Handling Equipment Makes It Possible To Combine The New Granulation Unit To A Compact Line, For Instance With The New Tablet Presses Of The Manesty TPR Range. Alternatively, The Granule Can Be Filled Into Stick Packs Or Capsules, For Example With The New GKF 2600 Capsule Filling Machine From Bosch.