-
Min. Order (MOQ)
10 Gram
-
Brand Name
Demeikai
-
CAS No.
202350-68-3
-
Purity
99
-
Country of Origin
China
-
MW:
641.62
-
Molecule Formula:
C32H35NO13
-
Purity :
>98%
Pnu-159682 basic info.Product name:pnu-159682 cas no.:202350-68-3mw: 641.62molecule formula: c32h35no13 purity :>98%solubility:dmsomechanisms: pathways:cell cycledna damage; target:topoisomerasepathways:antibody-drug conjugatesadcs related; target:adcs cytotoxinbiological activity:pnu-159682 is a major bioactive metabolite of nemorubicin in human liver microsomes; > 3, 000-foldcytotoxic than its parent compound(mmdx and doxorubicin).Ic50 value: 0.1-0.5 nm (ht-29; du145; jurkat cell lines, etc) [1]target: topoisomerase I inhibitorin vitro: the cytotoxicity of pnu-159682 were in the subnanomolar range (0.07-0.58 nmoll) and noticeablylower than that recorded for both mmdx and doxorubicin; pnu-159682 was 2, 360- to 790-fold and 6, 420- to2, 100-fold more potent than mmdx and doxorubicin, respectivelyin vivo: an evaluation of the in vivo antitumor activity of pnu-159682, in comparison with that of mmdx, wasthen conducted in mice bearing disseminated murine l1210 leukemia. Preliminary toxicity dose-findingstudies showed that 15 agkg i.v. Was the single-dose maximum tolerated dose of pnu-159682
wuhan, China
Write a Review
Celia (Wuhan Deme chem Biotechnology Co Ltd)
Share us via
