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Nature of Business Supplier Year of Establishment 2016Ask for more detail from the seller
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Pnu-159682 basic info.
Product name:pnu-159682
cas no.:202350-68-3
mw: 641.62
molecule formula: c32h35no13
purity :>98%
solubility:dmso
mechanisms: pathways:cell cycledna damage; target:topoisomerase
pathways:antibody-drug conjugatesadcs related; target:adcs cytotoxin
biological activity:
pnu-159682 is a major bioactive metabolite of nemorubicin in human liver microsomes; > 3,000-foldcytotoxic than its parent compound(mmdx and doxorubicin).
Ic50 value: 0.1-0.5 nm (ht-29; du145; jurkat cell lines, etc) [1]
target: topoisomerase I inhibitor
in vitro: the cytotoxicity of pnu-159682 were in the subnanomolar range (0.07-0.58 nmoll) and noticeablylower than that recorded for both mmdx and doxorubicin; pnu-159682 was 2,360- to 790-fold and 6,420- to2,100-fold more potent than mmdx and doxorubicin, respectively
in vivo: an evaluation of the in vivo antitumor activity of pnu-159682, in comparison with that of mmdx, was
then conducted in mice bearing disseminated murine l1210 leukemia. Preliminary toxicity dose-finding
studies showed that 15 agkg i.v. Was the single-dose maximum tolerated dose of pnu-159682
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