Traditional Heating & Cooling Systems

Active Pharmaceutical Ingredient (API) manufacturing involves batch reaction, work-up, distillation, crystallization, hydrogenation, layer separation, filtration and drying as unit processes. Again, batch reaction involves heating and cooling stages ranging from -50°C to +250°C.
Traditionally, this was being done with multiple utilities such as chilled brine, chilled water, cooling water, hot water, low pressure steam, high pressure steam, thermic fluid etc.

Limitations

• Different heat transfer fluids (HTFs) may require separate coils, heating and cooling jacket zones or external heat exchangers.
• Time consuming changeover of HTFs and associated risks of human error.
• Cross contamination of HTFs.
• Multiple utilities can corrode the reactor jacket.
• Condensate recovery is not feasible.
• Inefficient management of HTFs leading to inaccurate temperature control.
• Process parameter deviations adversely affect product quality.
• Complicated mechanical design, and Increases capital/maintenance costs.

Traditional Heating & Cooling Systems

Active Pharmaceutical Ingredient (API) manufacturing involves batch reaction, work-up, distillation, crystallization, hydrogenation, layer separation, filtration and drying as unit processes. Again, batch reaction involves heating and cooling stages ranging from -50°C to +250°C.
Traditionally, this was being done with multiple utilities such as chilled brine, chilled water, cooling water, hot water, low pressure steam, high pressure steam, thermic fluid etc.

Limitations

• Different heat transfer fluids (HTFs) may require separate coils, heating and cooling jacket zones or external heat exchangers.
• Time consuming changeover of HTFs and associated risks of human error.
• Cross contamination of HTFs.
• Multiple utilities can corrode the reactor jacket.
• Condensate recovery is not feasible.
• Inefficient management of HTFs leading to inaccurate temperature control.
• Process parameter deviations adversely affect product quality.
• Complicated mechanical design, and Increases capital/maintenance costs.