Polylactide (Poly(lactic acid), PLA) is polymer obtained by the ring-opening polymerization of lactide (cyclic dimer of lactic acid) as monomer. Since lactide has 3 optical isomer as L-lactide, D-lactide, and DL-lactide, the polymers obtained from L-lactide, D-lactide, and DL-lactide are abbreviated to PLLA, PDLA, and PDLLA, respectively. The chemical properties of L-lactide and D-lactide are the same while their steric structures are different, PLLA polymer and PDLA polymer have the same characteristics. On the other hand, PDLLA polymer has sterically different structure with PLLA and PDLA polymers, so that the polymer shows the different characteristics with those polymers.

Chemical namePoly(DL-lactic acid)

• Poly-DL-lactide
• Poly[oxy(1-methyl-2-oxoethylene)]
• Poly[3, 6-dimehthyl-1, 4-dioxane-2, 5-dione]Chemical formula−(C3H4O2)n−
• −O−CO−CH(CH3)−Formula weight72.06266CAS number26680−10−4, 26100−51−6, 26023−30−3PoLyInfo PIDP090176, P902489CharacteristicsAmorphous polymer,

Transparent polymer

• Inherent viscosityηinh = 0.85 − 1.15 (dL/g) [0.5 g/dL CHCl3, 25 ¿¿¿]Weight averaged
• molecular weight(MW)MW = 100, 000 − 180, 000Glass transition
• point¿¿¿Tg¿¿¿Tg = 50 − 60 (¿¿¿)Particle sizeNot passing 500 µm mesh screen.AppearanceNo contamination by foreign objects
• Normal coloring (white or beige/ivory) (Sensory test with eye)

Properties Related Categories5 Arm Star PLGA (Lactide:Glycolide 50:50), Biodegradable Polymers, Lactide and Glycolide Polymers, Materials Science, Poly(Lactide-co-Glycolide) (PLGA) Copolymers, More.descriptionhydroxyl terminatedfeed ratiolactide:glycolide 50:50mol wtaverage M_n 50, 000degradation timeframe3-6 weeksmp270-275 °CM_w/M_nstorage temp.2-8°C

Application:

• Hetero bi functional degradable PLGA for conjugation, grafting and fictionalization for drug delivery applications
• Reported Drugs are
• Octreotide Acetate (Sandostatin Lar , Novartis)

Acid capped poly(D, L-lactide-co-glycolide) (PLGA-acid, PLGA-COOH, PLGA acid terminated, D, L-LA/GA=50:50) can be used to prepare nanoparticles, which can be further modified by amine-reactive entities. PLGA-COOH can be used to prepare polymer-drug conjugates.

Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained- release properties, low toxicity, and bio compatibility with tissue and cells.

Product Details:

• Identifiers CAS Number: 26100-51-6
• Chem Spider: none
• ECHA InfoCard100.128.355Properties
• Density1.210–1.430 g·cm−3
• [1]Melting point150 to 160 °C (302 to 320 °F; 423 to 433 K)
• [1]Solubility in water Insoluble in water
• [2] Hazards NFPA 704100Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

The traditional role of PGA as a biodegradable suture material has led to its evaluation in other biomedical fields. Implantable medical devices have been produced with PGA, including anastomosis rings, pins, rods, plates and screws.[2] It has also been explored for tissue engineering or controlled drug delivery. Tissue engineering scaffolds made with polyglycolide have been produced following different approaches, but generally most of these are obtained through textile technologies in the form of non-woven meshes.

• Biodegradable polymer. Decomposes in 6 months at 37° at pH 9.0.
• Synonyms:polyglycolide, PGA
• CAS#: 26124-68-5
• Formula:
• H(OCH₂CO)_nOH
• Molecular Weight: >100, 000
• Tg: 36°
• Soluble In: HFIP, HFA-sesquihydrate
• TSCA
• Hazards: Harmless-use normal precautions , Hygroscopic
• Handling: Exercise normal care
• Storage: Protect from moisture;Store below 0° C

PLA is biocompatible and thus suitable for medical use, for instance in absorbable suture threads. PLA based materials have been extensively used as fixation-devices such as screws, pins, washers, darts, and arrows in reconstructive surgeries. PLA is also one of the few plastics that are suitable for 3D printing The traditional role of PGA as a biodegradable suture material has led to its evaluation in other biomedical fields.