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4-Hydroxy Coumarin-d4 is the isotope labelled analog of 4-Hydroxy Coumarin, a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 integrase. 4-Hydroxy Coumarin-d4 is also a useful synthetic intermediate in the synthesis of 4’-Hydroxy Warfarin-d4.