Abnormal Toxicity Testing Services

The ATT is a quality control test that is used by manufacturers and national control laboratories (NCLs) in different countries for batch release testing. It's a crucial component of safety measures for vaccines and is recommended by the World Health Organization to be incorporated into national vaccine control procedures. 

The ATT involves a single injection of a specified volume of a product batch into guinea pigs and/or mice, followed by an observation period. The test evaluates the material over a few days for evidence of toxicity, such as survival and body weight loss. A batch typically passes the test if the findings seen in animals follow certain criteria, such as surviving the test period and weighing no less at the end of the test period than at the time of injection. 

The ATT can help identify non-specific toxicity, contamination from exogenous substances, and potential toxic effects early in the development trajectory. However, the test has some limitations, such as poor reliability due to the animal model and the questionable transferability of the test results to the target species.