Acyclovir

Acyclovir
english name: aciclovir
name: axiluowei
chinese alias: acyclovir, acg, aciclovir, acyclovir, aciclovir, lose dimension treatment static, aciclovir, acycloguanosine, acyclovir, acyclovir, acycloguanosine, zovirax.
Category: antiviral drug
properties: this product is white
chemical name 9- (2- hydroxyethyl yang jiaji) guanine
name axiluowei
english name aciclovir tablets
cas:59277-89-3
the molecular formula c8h11n5o3
a molecular weight of 225.21
disease resistant poison. In vitro on herpes simplex virus, varicella zoster virus, cytomegalovirus etc.
A silowe
inhibitory effect of. The products entering the herpes virus infected cells, and deoxynucleoside competition virus thymidine kinase or cellular kinases phosphorylate activated, the drug was acyclovir three phosphate, and then through the two ways to inhibit virus replication:
the interference of viral dna polymerase, suppression of viral replication;
in the dna polymerase function, combined with the growth of the dna chain and dna chain elongation caused by interruption. The product of the virus has a special affinity, but low toxicity to mammalian host cells. In vitro cell transformation assay have carcinogenic reports, but no carcinogenic according to animal experiment. Some animal experiments showed that high concentrations of drugs can cause mutation, but no chromosomal change basis.
Carcinogenic and mutagenic effects of the goods is not clear. Injection of large dosage can cause animal atrophy of testis and sperm count reduced, drugs can pass through the placenta, animal experiments confirmed that no effect on embryo.