Apixaban, Form : Powder

Niksan Pharmaceutical is one of the biggest manufacturer, supplier, exporter and trader of the Apixabanfinished formulations moreover Apixaban API. Niksan Pharmaceutical is the huge manufacturer, exporter and supplier of Apixaban API and formulation situated in Ankleshwar, Gujarat, India.

Niksan Pharmaceutical is the suppliers, manufacturer, exporters and trader of
Apixaban inthe domestic level as well as the international market.

Niksan is an Indian based pharmaceutical company so it also supplies and manufactures the Apixaban to all Indian states like Gujarat, Maharashtra, Punjab, Delhi, Tamilnadu, Goa, Uttar Pradesh, Karnataka, Jammu & Kashmir, West Bengal, Assam, Rajasthan, Hyderabad, Karnataka, Kerala, Madhya Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Orissa, Punjab and Haryana.  

Niksan Pharmaceutical and Niksan group companies are exporters, suppliers and manufacturers of the API and also Apixaban formulations in many countries for many years. Niksan pharmaceutical currently exports Apixaban API and Formulation to countries like New Zealand, Jordan, Belgium, United Kingdom, Australia, Italy, Ireland, Hong Kong, Morocco, Portugal, France, South Africa, Philippines, Malaysia, Singapore, Israel, Greece, Saudi Arabia, Egypt, Taiwan, Netherlands, South Korea, Switzerland, Algeria, Pakistan, Canada, Vietnam, United States, Germany, Brazil and many other countries.

Apixaban is a novel oral anticoagulant (NOAC) that functions as a selective Factor Xa inhibitor. It is used to prevent and treat blood clots such as deep vein thrombosis (DVT) and pulmonary embolism (PE), and to reduce the risk of stroke in patients with non-valvular atrial fibrillation.

SYNONYSMS:Eliquis

IUPAC NAME: 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

CAS NO:503612-47-3

FORMULA:C25H25N5O4

MOLECULAR MASS:  459.50 g/mol

STORAGE CONDITIONS:Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15–30°C. Protect from moisture and light. Store in a tightly closed container.

HOW TO USE:Apixaban is usually taken orally twice daily, with or without food. The dosage varies depending on the indication (e.g., 2.5 mg or 5 mg twice daily). Strictly follow the physician’s prescription and do not discontinue abruptly.

HOW APIXABAN WORKS:Apixaban selectively inhibits Factor Xa, an essential enzyme in the coagulation cascade, thereby preventing the formation of thrombin and fibrin clots. It reduces the risk of thromboembolic events without the need for routine blood monitoring.

PHARMACOKINETICS OF APIXABAN:Apixaban is absorbed with ~50% bioavailability, reaching peak plasma concentrations in 3–4 hours. It is partially metabolized by CYP3A4 and excreted via urine and feces. Its half-life is approximately 12 hours.

SIDE EFFECTS OF APIXABAN: The Common Side Effects Of Apixaban AreBleeding (major and minor), Anemia, Nausea, Hypotension, Bruising, Allergic reactions (rare).

PRECAUTIONS: Use with caution in patients with renal or hepatic impairment. Avoid concomitant use with other anticoagulants. Not recommended in patients with active bleeding. Discontinue before surgical procedures. Monitor for signs of bleeding and anemia.

CDSCO APPROVAL:

Apixaban Tablets 2.5mg 03.08.2012

Apixaban tablets 2.5mg/5mg (Additional Strength & Additional Indication) 16.05.14

Apixaban Tablets 2.5/5mg (additional Indication) 29.05.15

FORMULATIONS AVAILABLE IN MARKET:

APIXABAN 2.5 MG Tablets

APIXABAN 5 MG Tablets

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk