Atovaquone

Proguanil (Malarone) (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.
PREPARATIONS: Atovaquone and proguanil tablets are available in two combination strengths: 250100 mg (adults) and 62.525 mg (pediatric).
STORAGE: Store Atovaquone and proguanil tablets should be stored between 15 C to 30 C (59 F to 86 F).
Atovaquone and proguanil is an anti-malarial medication. Atovaquone (Malorone) blocks mitochondrial electron transfer and thereby the production of energy for use by the parasites. Proguanil is metabolized into its active metabolite, cycloguanil, which blocks dihydrofolate reductase and enzymes required for making pyrimidine which is a chemical needed for production of DNA.
Start prophylaxis 1 or 2 days before entering a malaria-endemic area and continue during the stay and for 7 days after return.
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.