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Chlorambucil is a cancer medication that interferes with cancer cells and slows their growth and spread in the body. Chlorambucil is used to treat several types of cancer, including hodgkin's disease and certain types of leukemia or lymphoma. Chlorambucil may also be used for other purposes not listed in this medication guide. What is the most important information I should know about clokeran (chlorambucil)? do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby.