Citicoline, Form : Tablets, Grade : Medicine Grade

Niksan Pharmaceutical is leading manufacturer and distributer of the Citicolineamong the other countries. Niksan Pharmaceutical is one of the major the supplier, distributer, exporter and manufacturer of the Citicoline API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.

Niksan Pharmaceutical is the supplier, manufacturer, exporter and trader of Citicoline in the domestic level as well as the international market. 

Niksan Pharmaceutical provides Citicoline API in all over Indian states like Jammu & Kashmir, Himachal Pradesh, Uttarakhand, Punjab, Kerala, Chandigarh, Chhattisgarh, Andhra Pradesh, Rajasthan, Meghalaya, Mizoram, Nagaland, Orissa, Pondicherry, Dadra and Nagar Haveli, Goa, Gujarat, Jharkhand, West Bengal, Karnataka, Kerala, Madhya Pradesh etc.

Niksan Pharmaceutical also provides Citicoline API and finished formulations in all other countries of the world like Germany, Switzerland, Poland, Latvia, Egypt, Lithuania, Estonia, Ukraine, Moldova, Russia, United States, Austria, Belarus, Serbia, India, Spain, Slovenia, Nigeria, Croatia, South Africa, Kazakhstan, Italy, Romania, Bulgaria, Portugal, South Korea, Greece, Philippines, Belgium, Saudi Arabia, Turkey, Japan etc.

Citicoline is one type of diuretic medication which is used to treat stroke, head trauma or injury, Alzheimer's disease, Parkinson's disease, and glaucoma. A stroke occurs due to insufficient blood supply to the brain. Alzheimer's disease is a progressive age-related memory loss.

SYNONYMS: CDP-Choline, CDP-Cholina, Citicolina, Citicoline, Citidin Difosfato De Colina

IUPAC NAME: {2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphono)oxy]ethyl}trimethylazanium

CAS NO: 987-78-0

FORMULA: C₁₆H₂₀N₄O₃S

MOLECULAR MASS:488.12 g/mol

STORAGE OF CITICOLINE:Keep container tightly closed in a dry and well-ventilated place.

APPLICATIONS OF CITICOLINE: Uses of citicoline for age-related decline in memory and thinking, glaucoma, stroke, Alzheimer disease, bipolar disorder, depression, and many other conditions, but there is no good scientific research to support most of these uses.

HOW TO USE: Citicoline has most often been used by adults in doses of 500-1000 mg by mouth twice daily for up to 12 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

HOW CITICOLINE WORKS: Citicoline seems to increase a brain chemical called phosphatidylcholine. Citicoline might also increase the amounts of other chemicals that send messages in the brain. It was originally used as a drug to help improve memory and brain function after a stroke.

CONTRAINDICATIONS OF CITICOLINE: Avoid giving high dose citicoline (>500 mg) in intracranial bleeding. Pregnancy and lactation. Cardiac disorders: Bradycardia, tachycardia. Eye disorders: Diplopia.

PHARMACOKINETICS OF CITICOLINE: Citicoline is water-soluble, with more than 90% oral bioavailability. Plasma levels peak one hour after oral ingestion, and a majority of the citicoline is excreted as CO ₂ in respiration, and again 24 hours after ingestion, where the remaining citicoline is excreted through urine.

SIDE EFFECTS OF CITICOLINE:  Citicoline was well tolerated in clinical trials. Adverse effects may include GI disturbances, transient headaches, hypotension, tachycardia, chest pain, irregular heartbeats, Loose motions, feeling sick (nausea), bradycardia, and restlessness.

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