Closantel Sodium, Brand Name : Closandot, CAS No. : 61438-64-0

Niksan Pharmaceutical is leading manufacturer and distributer of the Closantel Sodium among the other countries. Niksan Pharmaceutical is one of the major the supplier, distributer, exporter and manufacturer of the Closantel Sodium API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.

Niksan Pharmaceutical is the supplier, manufacturer, exporter and trader of Closantel Sodium in the domestic level as well as the international market. 

Niksan Pharmaceutical provides Closantel Sodium API in all over Indian states like Jammu & Kashmir, Himachal Pradesh, Uttarakhand, Punjab, Kerala, Chandigarh, Chhattisgarh, Andhra Pradesh, Rajasthan, Meghalaya, Mizoram, Nagaland, Orissa, Pondicherry, Dadra and Nagar Haveli, Goa, Gujarat, Jharkhand, West Bengal, Karnataka, Kerala, Madhya Pradesh etc.

Niksan Pharmaceutical also provides Closantel Sodium API and finished formulations in all other countries of the world like Germany, Switzerland, Poland, Latvia, Egypt, Lithuania, Estonia, Ukraine, Moldova, Russia, United States, Austria, Belarus, Serbia, India, Spain, Slovenia, Nigeria, Croatia, South Africa, Kazakhstan, Italy, Romania, Bulgaria, Portugal, South Korea, Greece, Philippines, Belgium, Saudi Arabia, Turkey, Japan etc.

Closantel Sodium is one type of synthetic anti parasitic agent which is highly effective against adults and larvae (6 to weeks old) of liver flukes (Fasciola hepatica), and against several important gastrointestinal roundworms. 

SYNONYMS: Closantel sodium, Closantel (sodium)

IUPAC NAME: sodium;2-[[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]carbamoyl]-4,6-diiodophenolate

CAS NO: 61438-64-0

FORMULA: C₂₂H₁₃Cl₂I₂N₂NaO₂

MOLECULAR MASS: 685.1  g/mol

STORAGE OF CLOSANTEL SODIUM:Store at room temperature.

APPLICATIONS OF CLOSANTEL SODIUM: Closantel is a synthetic anti parasitic agent which is highly effective against adults and larvae (6 to weeks old) of liver flukes (Fasciola hepatica), and against several important gastrointestinal roundworms (e.g. Bunostomum, Haemonchus, Oesophagostomum, Ostertagia - Teladorsagia, Strongyloides, Trichostrongylus).

HOW TO USE:  5.25 g of closantel sodium, 1 g of hydroxypropyl cyclodextrin and 0.5 g of povidone are dissolved in each 100 mL of the mixed solvent.

HOW CLOSANTEL SODIUM WORKS: causes an initial burst of contractions of much greater amplitude and frequency than normal in tissue vessel, the stimulation of amplitude and frequency lasted for nearly 15 min and is accompanied by a rise in muscle tone, which reaches a maximum at 16 min, at a level greater than 1.5 times.

CONTRAINDICATIONS OF CLOSANTEL SODIUM: It is widely used in management of parasitic infestation in animals but is contraindicated in humans and in high dose in milk producing animals because of its secretion in milk.

PHARMACOKINETICS OF CLOSANTEL SODIUM: Rapidly absorbed into the systemic circulation with peak plasma levels at 24-48 hours after dosing. In plasma, closantel is bound 99% to albumin.

SIDE EFFECTS OF CLOSANTEL SODIUM Its inhibition interrupts their development to adult worms. This drug possesses some side effects: hyper acute anaphylactic reactions in cattle; hypersensitivity reactions; overdoses can cause reduced visibility or blindness, anorexia, lack of coordination and general weakness.

PRECAUTIONS:

P202 Do not handle until all safety precautions have been read and understood.

P260 Do not breathe mist or vapors. P264 Wash skin thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk