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Colistimethate sodium is a cyclic polypeptide antibiotic derived from Bacillus polymyxa
var. colistinus and belongs to the polymyxin group. The polymyxin antibiotics are
cationic surface-active agents that work by damaging the cell membrane. The resulting
physiological effects are lethal to the bacterium. Polymyxins are selective for Gramnegative
bacteria that have a hydrophobic outer membrane.