Commiphora Mukul Extract

Guggul is the yellowish resin (or gum) that is produced by Commiphora mukul, a small, thorny plant that grows throughout northern India. Its active components, Z-guggulsterone and E-guggulsterone, have an ability to lower both cholesterol and triglyceride levels. Specifically, guggulipid lowers VLDL and LDL cholesterol and triglycerides while simultaneously raising HDL cholesterol.

This indicates guggul's primary use for providing protection against atherosclerosis. These effects are due to guggul's action on the liver which is stimulated to metabolise LDL cholesterol, effectively lowering the amount in the bloodstream.

Native to India, Guggul lipid has been used for a long time in Ayurvedic medicine to treat obesity and other weight related problems. Today, Guggul is frequently used to help lower cholesterol levels and decrease high blood pressure.

In chemical composition guggulu (extracted resin) consist of octanordammarana terpenes manusumbionic acid and manusumbinone as obtained from chemical analysis.

One of the main uses of Guggul is treatment of high cholesterol. Gum Guggul both lowered cholesterol levels and also separately protected against the development of hardening of the arteries. Guggul can improve cholesterol levels. Gum Guggul is said to help reduce high cholesterol, because it lowers harmful low-density lipoproteins while elevating the beneficial high-density lipoproteins.

Guggul may lower serum cholesterol levels by as much as 24%, and triglyceride levels by as much as 23%, by increasing the hepatic binding of LDL cholesterol. Its effects on HDL cholesterol levels are variable, either increasing or decreasing.

The guggulsterone, the active ingredient in the guggul extract, blocks the activity of a receptor in the liver's cells called Farnesoid X Receptor (FXR). Guggul blocks the receptor and affects how cholesterol is metabolised.

• A small controlled trial compared oral gugulipid against tetracycline for the treatment of acne and reported equivalent results.
• Guggul is also widely promoted as a weight loss agent.
• Helps prevent blood platelet aggregation and break up already-formed blood clots. Thus, this activity can help prevent heart disease and stroke. Guggul lipids have been the subject of several scientific studies, the results of which have been extremely encouraging as to the product's nutritional value to the circulatory system.
  It is a heart tonic that strengthens the heart. Guggulsterone stimulates the thyroid gland, has anti-inflammatory properties, and protects against myocardial necrosis resulting from drug toxicity.
  It helps in lowering in blood pressure levels and helps in maintaining it to normal levels.