Cycloboon ER 15 Cyclobenzaprine Tablet

Cyclobenzaprine Hydrochloride is a well-studied skeletal muscle relaxant. Here is a more detailed description covering its use, mechanism, dosage, and warnings.

Detailed Description of Cyclobenzaprine Hydrochloride Tablets

1. Classification and Chemical Structure

• Classification: Cyclobenzaprine is a centrally-acting skeletal muscle relaxant. It is chemically related to the tricyclic antidepressants (TCAs), sharing a similar chemical structure (a tricyclic amine salt).

• Brand Names: It is sold under various brand names (e.g., Flexeril, Fexmid) and as a generic.

• Chemical Properties: Cyclobenzaprine hydrochloride is a white, crystalline solid that is freely soluble in water and alcohol.

2. Primary Use and Efficacy

• Indication: Cyclobenzaprine is indicated as an adjunct (supplement) to rest and physical therapy for the relief of muscle spasm associated with acute, painful musculoskeletal conditions. It works to relieve associated pain, tenderness, and limitation of motion.

• Not for Chronic Use: It is intended only for short-term use (typically 2 to 3 weeks) because muscle spasms from acute injuries are usually short-lived, and there is no evidence of effectiveness for more prolonged use.

• Mechanism of Action (Pharmacology):

  • It does not act directly on the muscles or the neuromuscular junction.

  • It is believed to act primarily on the central nervous system, specifically at the brain stem level, to reduce tonic somatic motor activity (the continuous tension in muscles).

  • It may modulate the serotonergic and noradrenergic systems and has anticholinergic effects (blocking muscarinic acetylcholine receptors), which is thought to contribute to its sedative properties.

3. Dosage and Administration

• Immediate-Release (IR) Tablet Dosage:

  • The typical starting dosage for most adults (15 years and older) is 5 mg taken three times daily (TID).

  • Based on patient response, the dose may be increased to 10 mg three times daily.

  • The maximum recommended daily dose should generally not exceed 60 mg.

  • The tablets can be taken with or without food.

4. Important Warnings and Contraindications

Cyclobenzaprine is associated with several important warnings, primarily due to its similarity to tricyclic antidepressants.

5. Common and Serious Side Effects

Important Note for the Elderly: Older adults are more susceptible to side effects like confusion, hallucinations, and heart rhythm changes. A lower dosage is typically recommended if use is necessary.

Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult with a doctor or pharmacist regarding prescription medication.