Delta Sleep-inducing Peptide

We offer delta sleep-inducing peptide. Dsip (delta sleep-inducing peptide)
delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia.
Abstract
background and objective:
delta sleep-inducing peptide (dsip) is an endogenous peptide that crosses the blood-brain barrier, named after its association with natural sleep and enhanced electroencephalogram (eeg) delta rhythm. The objective of this study was to determine whether dsip could be used as an adjunct to volatile anaesthesia in humans, our hypothesis being that dsip is a natural hypnotic that would increase anaesthetic depth. The aims were to assess depth of anaesthesia using bispectral index (bis), the eeg and heart rate variability (hrv), and to determine whether dsip altered the symmetry of eeg between the left and right cerebral hemispheres.
Results:
dsip significantly increased heart rate, decreased hrv and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing bis at 25 nmol kg(-1) during isoflurane anaesthesia. Dsip also significantly altered bilateral symmetry of eeg.
Conclusion:
dsip probably reduced parasympathetic tone and decreased (lightened) the depth of anaesthesia measured using bis.