Diclofenac Sodium

We are offering diclofenac sodium is the salt form of diclofenac, an active metabolite of the said aceclofenac (sc - 217557). Hydrolysis of aceclofenac, an inhibitor of interleukin - 1b - induced prostaglandin e2 production with no inhibitory activity against cox (cyclooxy genase), generates diclofenac, which inhibits both cox-1 and cox-2 oxidation of diclofenac produces the metabolite h’-hydroxy. Diclofenac demonstrates specific inhibition of cox-2. Inhibition of cox by diclofenac and h’-hydroxy diclofenac suppress protaglandin e2 synthesis, producing anti inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (ttr) fibrils, preventing the formation of insoluble amyloidogenic ttr deposits. description :

• cas no. : 15307-79-6
• molecular weight : 318.1
• molecular formula : c14h10cl2no2na
• white solid
• purity : 99%
• solubility : soluble in ethanol dmso or dmf (35mg/ml), soluble in buffers of ionic strength 0.1m and ph 7.2 (9mg/ml)
• boiling point : h12 degree celsius
• boiling point pressure : 203 degree celsius
• melting point : 288 - 290 degree celsius
• vapor pressure : 1.59 e - 07mm hg at 25 degree celsius
• uv absorption : may 285 nm

• diclofenac sodium
• diclofenac potassium
• diclofenac diethylammoium
• diclofenac diethylamine, etc.

• it is available in export worthy drums of 25/50 kilos or as required by our customers