Duloxetine HCL, CAS No. : 136434-34-9, Purity : Often 99% OR Greater

Niksan Pharmaceutical is one of the biggest manufacturer, supplier, exporter and trader of the DULOXETINEfinished formulations moreover Duloxetine API. Niksan Pharmaceutical is the huge manufacturer, exporter and supplier of Duloxetine API and formulation situated in Ankleshwar, Gujarat, India.

Niksan Pharmaceutical is the suppliers, manufacturer, exporters and trader of
Duloxetine inthe domestic level as well as the international market.

Niksan is an Indian based pharmaceutical company so it also supplies and manufactures the Duloxetine to all Indian states like Gujarat, Maharashtra, Punjab, Delhi, Tamilnadu, Goa, Uttar Pradesh, Karnataka, Jammu & Kashmir, West Bengal, Assam, Rajasthan, Hyderabad, Karnataka, Kerala, Madhya Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Orissa, Punjab and Haryana.  

Niksan Pharmaceutical and Niksan group companies are exporters, suppliers and manufacturers of the API and also Duloxetine formulations in many countries for many years. Niksan pharmaceutical currently exports Duloxetine API and Formulation to countries like New Zealand, Jordan, Belgium, United Kingdom, Australia, Italy, Ireland, Hong Kong, Morocco, Portugal, France, South Africa, Philippines, Malaysia, Singapore, Israel, Greece, Saudi Arabia, Egypt, Taiwan, Netherlands, South Korea, Switzerland, Algeria, Pakistan, Canada, Vietnam, United States, Germany, Brazil and many other countries.

DULOXETINEis a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.

SYNONYSMS:Cymbalta

IUPAC NAME: (+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride

CAS NO:136434-34-9

FORMULA:C18H19NOS

MOLECULAR MASS: 297.42g/mol

STORAGE CONDITIONS:Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F). Store in a dry place in tightly closed containers.

HOW TO USE:Duloxetine is typically taken once or twice daily with or without food. The starting dose is usually 30 mg to 60 mg once daily. Dosage can be adjusted by a healthcare provider depending on the condition and patient response.

HOW DULOXETINE WORKS:Duloxetine works by increasing the levels of serotonin and norepinephrine in the central nervous system. These neurotransmitters are believed to have a positive effect on mood and pain perception, making Duloxetine effective for both mood and pain disorders.

PHARMACOKINETICS OF DULOXETINE:Duloxetine is well absorbed after oral administration, reaching peak plasma concentrations in 6 hours. It undergoes extensive hepatic metabolism primarily via CYP1A2 and CYP2D6. The elimination half-life is approximately 12 hours, and the drug is excreted in urine.

SIDE EFFECTS OF DULOXETINE: The normal side effects caused by Duloxetine Nausea, Dry mouth, Fatigue, Dizziness, Constipation, Insomnia, Increased blood pressure, Decreased appetite, Liver enzyme elevations (rare)

PRECAUTIONS: Use with caution in patients with liver or kidney impairment, history of seizures, or those on MAO inhibitors. Gradual dose reduction is recommended when discontinuing. Monitor for signs of suicidal thoughts, especially in adolescents and young adults.

CDSCO APPROVAL:

Duloxetine hcl enteric coated tablets 02/11/2004

Duloxetine HCl capsules 02/03/2005

Duloxetine HCl (60mg) tablet (additional strength) 28/02/2005

FORMULATIONS AVAILABLE IN MARKET:

DULOXETINE 20 MG Capsules

DULOXETINE 30 MG Capsules

DULOXETINE 40 MG Capsules

DULOXETINE 60 MG Capsules

DULOXETINE Tablets

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

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