Enalapril Maleate Tablets, Brand Name : Newlystar

We are offering enalapril maleate tablets each tablet for oral administration, contains 5 mg, 10 mg or 20 mg of enalapril maleate.
Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ace) in human subjects and animals. Ace is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin ii. Angiotensin ii also stimu-lates aldosterone secretion by the adrenal cortex. The beneficial effects of enalapril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Inhibition of ace results in decreased plasma angiotensin ii, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Although the latter decrease is small, it results in small increases of serum potassium. In hypertensive patients treated with enalapril alone for up to 48 weeks, mean increases in serum potassium of approximately 0.2 meql were observed. In patients treated with enalapril plus a thiazide diuretic, there was essentially no change in serum potassium. (see precautions.) removal of angiotensin ii negative feedback on renin secretion leads to increased plasma renin activity.