Esomeprazole, Color : White, CAS No. : 144060-53-7

Niksan Pharmaceutical is leading manufacturer and distributer of the Esomeprazole among the other countries. Niksan Pharmaceutical is one of the major the supplier, distributer, exporter and manufacturer of the Esomeprazole API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.

Niksan Pharmaceutical is the supplier, manufacturer, exporter and trader of Esomeprazole in the domestic level as well as the international market. 

Niksan Pharmaceutical provides Esomeprazole API in all over Indian states like Jammu & Kashmir, Himachal Pradesh, Uttarakhand, Punjab, Kerala, Chandigarh, Chhattisgarh, Andhra Pradesh, Rajasthan, Meghalaya, Mizoram, Nagaland, Orissa, Pondicherry, Dadra and Nagar Haveli, Goa, Gujarat, Jharkhand, West Bengal, Karnataka, Kerala, Madhya Pradesh etc.

Niksan Pharmaceutical also provides Esomeprazole API and finished formulations in all other countries of the world like Germany, Switzerland, Poland, Latvia, Egypt, Lithuania, Estonia, Ukraine, Moldova, Russia, United States, Austria, Belarus, Serbia, India, Spain, Slovenia, Nigeria, Croatia, South Africa, Kazakhstan, Italy, Romania, Bulgaria, Portugal, South Korea, Greece, Philippines, Belgium, Saudi Arabia, Turkey, Japan etc.

Esomeprazole is one type of medication which is works by decreasing the amount of acid made in the stomach.

SYNONYMS: (S)-omeprazole, Esomeprazol, Ésoméprazole, Esomeprazole, Esomeprazolum, Perprazole

IUPAC NAME:5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole

CAS NO: 119141-88-7

FORMULA: C₁₇H₁₉N₃O₃S

MOLECULAR MASS: 345.4 g/mol

STORAGE OF ESOMEPRAZOLE:Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.

APPLICATIONS OF ESOMEPRAZOLE: esomeprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach) in adults and children 1 year of age and older.

HOW TO USE: Usually take esomeprazole once a day, first thing in the morning. You can take it with or without food. If you take esomeprazole twice a day, take 1 dose in the morning and 1 dose in the evening. Swallow tablets and capsules whole with a drink of water (non-fizzy).

HOW ESOMEPRAZOLE WORKS: Esomeprazole is a type of medicine called a proton pump inhibitor (PPI). Proton pumps are enzymes in the lining of your stomach that help it make acid to digest food. Esomeprazole prevents proton pumps from working properly. This reduces the amount of acid the stomach makes.

CONTRAINDICATIONS OF ESOMEPRAZOLE:  contraindicated in patients with known hypersensitivity to substituted benzimidazoles or to any component of the formulation. Hypersensitivity reactions may include anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute interstitial nephritis, and urticaria

PHARMACOKINETICS OF ESOMEPRAZOLE: Esomeprazole is extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system. The major part of esomeprazole's metabolism is dependent upon the CYP2C19 isoenzyme, which forms the hydroxy and desmethyl metabolites. The remaining amount is dependent on CYP3A4 which forms the sulphone metabolite.

SIDE EFFECTS OF ESOMEPRAZOLE:  Headaches. Make sure you rest and drink plenty of fluids. ...,Feeling sick, Try taking esomeprazole with or after a meal or snack. ...,Being sick. Take, small, frequent sips of water to avoid, dehydration, Diarrhoea, Constipation, Stomach pain, Farting (flatulence).

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