Fosfomycin Sodium

Fosfomycin Sodium
Synonyms: phosphomycin disodium salt
CAS: 26016-99-9
EINECS: 247-409-2
Assay: 99% min.
Standard: EPBPUSP
Packing: 25Kgcardboard drum
Character: Room temperature a white crystalline powder, hygroscopic, easily soluble in water, dissolution heat.
Usage: Disodium Phosphonomycin is a broad-spectrum antibiotics, Mainly used for chickens, ducks, pigs, staphylococcus, streptococcus, E. coli, Salmonella and other gram-negative bacteria cause acute and chronic intestinal diseases.
For the treatment of intestinal infection, with β-lactams, aminoglycosides in combination.
For Staphylococcus aureus infection cure, should be with erythromycin, rifampin combination.
For the treatment of severe respiratory tract infections, sepsis, peritonitis, etc. to increase the dose. Need and β-lactam or aminoglycoside combination.
1. Antibacterial spectrum, bioavailability, faster absorption, antimicrobial and strong, not diet affected. Against Gram-positive bacteria, negative bacteria have a role in the killing, especially Pseudomonas aeruginosa, Proteus, Salmonella, and a variety of pharmaceutical resistant Staphylococcus aureus and E. coli are able to show excellent antibacterial activity. For animals, there is no resistance and cross-resistance, good clinical outcomes.
2. Bactericidal quickly: This is a fast fungicides, and its role in the 1-2 hours later is already evident. About 25% of E. coli in contact with fosfomycin (12.5μgml) was 1 hour after the killing, and all died within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were also at 4 and 8 hours were all killed.
3. Low toxicity, irritation on the body, does not have acute toxicity and adverse reactions, without increasing the burden on the kidneys.
4. residue: in the muscles and organs to achieve the elimination of residual standard time is 48-72 hours.