Ganciclovir

We are offering ganciclovir cas no 82410-32-0.

ganciclovir usp30
cas no: 82410-32-0
molecular formula: c9h13n5o4
molecular weight: 255.23

ganciclovir usp30
cas no: 82410-32-0
molecular formula: c9h13n5o4
molecular weight: 255.23
appearance: white crystalline powder relative matter : ≤1.0% limit of guanine : ≤0.6% loss on dry : ≤6.0%
residue on ignition : ≤0.1% heavy metals : ≤10ppm assay : 98.0%-102.0%(hplc)

mechanism of action:

ganciclovir isasynthetic analogue of 2'-deoxy-guanosine. It is first phosphorylated toadeoxyguanosine triphosphate (dgtp) analogue. This competitively inhibits the incorporation of dgtp by viral dn apolymerase, resulting in the termination of elongation of viral dna.

pharmacokinetics:

absorption of the oral form is very limited - about 5% fasting, about 8% with food. It achievesaconcentration in the central nervous system of about 50% of the plasm alevel. About 90% of plasm aganciclovir is eliminated unchanged in the urine, withahalf-life of 2-6 hrs, depending on renal function (elimination takes over 24 hours in end-stage renal disease).