Optusan Macitentan Tablets, Color : White, Purity : 99 %

Macitentan 10mg tablets are an oral medication used to treat pulmonary arterial hypertension (PAH), which is a condition characterized by high blood pressure in the arteries that carry blood from the heart to the lungs.

Here 's a description of Macitentan 10mg tablets:

Appearance:

• Typically, these are film-coated tablets, often described as round, biconvex, and white to off-white. They may be debossed with "10 " on one side to indicate the dosage.

   

   

Active Ingredient:

• Each tablet contains 10 mg of macitentan.

Mechanism of Action:

• Macitentan is classified as an endothelin receptor antagonist (ERA).

   

   

• In PAH, a natural substance called endothelin-1 (ET-1) is overproduced. ET-1 causes blood vessels, particularly those in the lungs, to narrow (vasoconstriction) and promotes the abnormal growth of cells in the vessel walls. This leads to increased pressure in the pulmonary arteries.

• Macitentan works by blocking the action of ET-1 on both ETA and ETB receptors. By doing so, it helps to:

   

   

  • Relax and widen the constricted blood vessels in the lungs, reducing the pressure.

     

     

  • Reduce the proliferation of cells in the pulmonary arteries, which contributes to the narrowing of these vessels.

• This dual action ultimately reduces the workload on the heart, improves blood flow to the lungs, and helps to delay disease progression and improve exercise capacity in patients with PAH.

   

   

Usage and Dosage:

• Macitentan 10mg tablets are usually taken once daily, with or without food.

   

   

• The tablets should be swallowed whole and not crushed, broken, or chewed.

   

   

• Treatment is typically initiated and monitored by a physician experienced in treating PAH.

Indications:

• Macitentan is primarily indicated for the long-term treatment of pulmonary arterial hypertension (WHO Group I) in adult patients, particularly those in WHO Functional Class II to III. This includes idiopathic and heritable PAH, PAH associated with connective tissue disorders, and PAH associated with corrected simple congenital heart disease. It helps to delay disease progression and reduce hospitalization for PAH.