Methotrexate

Listing ID #1708555

We are offering methotrexate.
Methotrexate is an antineoplastic antimetabolite with immunosup- pressant properties. It is an inhibitor of tetrahydrofolate dehydro- genase & prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of dna. Methotrexate is a folate analog metabolic inhibitor. The mechanism of action of metho- trexate is as a folic acid metabolism inhibitor.
Methotrexate is an antimetabolite and antifolate agent with antineo- plastic & immunosuppressant activities. Methotrexate binds to & inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of dna & rna syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
synonyms: (2s)-2-[[4-[(2, 4-diaminopteridin-6-yl) methyl-methylamino] benzoyl] amino] pentanedioic acid
cas number: 59-05-2, mol. Formula: c20h22n8o5, mol.weight: 454.44
methotrexate is a yellow crystaline powder. It is soluble in dmso (100 mm), and water (