Mitoxantrone Injection

It is a synthetic antineoplastic anthracenedione for intravenous use. Although its mechanism of action is not fully elucidated, it is a dna - reactive agent. It has a cytocidal effect on with proliferating and non proliferating cultured small cells suggesting lock of cell cycle specifically.
Composition : each ml contains:
mitoxantrone ------------------------2 mg
indications : it is used in the treatment of metastatic breast cancer and of non-hodgkin’s lymphomas, alone or with other agents. It may also be given to treat adult acute myeloid leukemia. Mitoxantrone has also been used in patients with hormone-refractory prostate cancer, liver cancer, and ovarian cancer. In addition, mitoxantrone is used in the management of secondary progressive or relapsing multiple sclerosis, to reduce neurological disability or the frequency of relapses.
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Contraindications : mitoxantrone for injection is contraindicated in patients who have demonstrated prior hypersensitivity to it.