Nicotinamide

Product Name:Nicotinamide

CAS:98-92-0

Appearance:White Crystalline Powder

MF:C6H6N2O

MW:122.12

Einecs:202-713-4

Export Markets:Global

Application:

Anxiety

Studies show that nicotinamide has anxiolytic (anti-anxiety) properties. It may work in a way similar to benzodiazepines.

Alzheimer's disease

It is an activator of sirtuins (but inhibits at higher doses) and has been reported to restore cognition in Alzheimer's disease transgenic mice. A safety study of niacinamide for the treatment of Alzheimer's disease is currently underway at the University of California, Irvine.

 Cancer

Nicotinamide conflicts as a chemo- and radio-sensitizing agent/cancer-growth-promoter by enhancing tumor blood flow, thus reducing tumor hypoxia. Niacinamide also inhibits poly(ADP-ribose) polymerases (PARP-1), enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy. PARP-1 appears to be an important target for triple negative breast cancers because the cells are sensitive to inhibition of PARP-1. Niacinamide is also used by some patients in combination with intravenous vitamin C therapy for cancer. It has also been seen to prevent immunosuppression caused by UVA and UVB radiation (so it could potentially be added to sunscreen).

Apoptosis

Nicotinamide can prevent apoptosis (programmed cell death) in cells exposed to agents that induce oxidative stress. Thus nicotinamide prevents apoptosis in human cortical neuronal cells when oxidative stress is induced by tertiary butylhydroperoxide, and in Jurkat (human T-cell lymphoma cells) when oxidative stress is induced by sodium deoxycholate.

Other

Nicotinamide reportedly increases the endurance of mice.