Peptidyl Dipeptidase Inhibitor

A potent and specific inhibitor of peptidyl-dipeptidase a. It blocks the conversion of angiotensin I to angiotensin ii, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the renin-angiotensin system and inhibits pressure responses to exogenous angiotensin. Captopril is an angiotensin converting enzyme inhibitor. The mechanism of action of captopril is as an angiotensin-converting enzyme inhibitor. Captopril is a sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ace), thereby decreasing levels of angiotensin ii, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (mmps) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. synonyms: (2s)-1-[(2s)-2-methyl-3-sulfanylpropanoyl] pyrrolidine-2-carboxylic acid cas number: 62571-86-2, mol. Formula: c9h15no3s, mol.weight: 217.29 captopril is a white to off-white, crystalline powder. It is soluble in water (160 mgml) at 25 °c, sesame and corn oils (100 mgml), ethanol (>100 mgml), isopropanol (>100 mgml), chloroform (>100 mgml), and dichloromethane (>100 mgml) with melting range of 104°cto 108°c. Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements