Pralidoxime Chloride

Chinese pralidoxime chloride
CAS NO 51-15-0
Quality standard CPV78 / USP32
characteristics this product is a white crystalline powder. This product soluble in water.
pharmacological action he strain oxime compounds, the quaternary ammonium groups can tend to combine with organophosphorus pesticides has lost vitality of phosphorus acylation of cholinesterase cation site, its nucleophilic groups can be directly combined with cholinesterase phosphorylation groups and then together out of cholinesterase, cholinesterase returned to square one, to show vitality, be of organophosphorus pesticide inhibit more than 36 hours to have "aging" of the resurrection of cholinesterase effect is poor. Is machine for chronic phosphorus insecticides poisoning inhibition of cholinesterase no resurrection. This product sample symptoms caused by organophosphorus pesticides, and weak effect on poison alkali symptoms, effect on the central nervous system symptoms is unclear. This hip content is 79.5%, and pralidoxime iodide only 51.9%; This article 1 g efficacy is equivalent to 1.5 g pralidoxime iodide. This product is water soluble (640 mg/ml, 25 ), good stability and local absorbed completely, for intramuscular injection. Report of 43 patients with organophosphorus pesticides poisoning, blood cholinesterase about 50% of the average energy is normal. Intramuscular injection of this product after 0.5 ~ 1 g, clinical symptoms were disappeared within 30 minutes ~ 1 small, blood cholinesterase activity more than 70% of the recovered to normal.